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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between thyroid function and Alzheimer's disease: A systematic review

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Figueroa, Paulina Belen Sepulveda [1, 2] ; Ferreira, Ana Flavia Fernandes [3] ; Britto, Luiz Roberto [3] ; Doussoulin, Arlette Patricia [4] ; Torrao, Andrea da Silva [2]
Total Authors: 5
[1] Univ La Frontera, Fac Med, Dept Preclin Sci, Temuco - Chile
[2] Univ Sao Paulo, Dept Fisiol Biofis, Lab Neuronal Commun, Av Prof Lineu Prestes, 1524 Cidade Univ, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Dept Fisiol Biofis, Lab Cellular Neurobiol, Av Prof Lineu Prestes, 1524 Cidade Univ0, BR-05508900 Sao Paulo, SP - Brazil
[4] Univ La Frontera, Dept Pediat & Child Surg, Temuco - Chile
Total Affiliations: 4
Document type: Review article
Source: METABOLIC BRAIN DISEASE; v. 36, n. 7, p. 1523-1543, OCT 2021.
Web of Science Citations: 1

Alterations in metabolic parameters have been associated with an increased risk of dementia, among which thyroid function has gained great importance in Alzheimer's disease (AD) pathology in recent years. However, it remains unclear whether thyroid dysfunctions could influence and contribute to the beginning and/or progression of AD or if it results from AD. This systematic review was conducted to examine the association between thyroid hormone (TH) levels and AD. Medline, ISI Web of Science, EMBASE, Cochrane library, Scopus, Scielo, and LILACS were searched, from January 2010 to March 2020. A total of 17 articles were selected. The studies reported alterations in TH and circadian rhythm in AD patients. Behavior, cognition, cerebral blood flow, and glucose consumption were correlated with TH deficits in AD patients. Whether thyroid dysfunctions and AD have a cause-effect relationship was inconclusive, however, the literature was able to provide enough data to corroborate a relationship between TH and AD. Although further studies are needed in this field, the current systematic review provides information that could help future investigations. (AU)

FAPESP's process: 20/02109-3 - Involvement of TRPM2 channel in neurodegeneration and microglial activation in a Parkinson's Disease model induced by 6-hydroxydopamine
Grantee:Ana Flávia Fernandes Ferreira
Support type: Scholarships in Brazil - Doctorate