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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrochemical Installation of CFH2-, CF2H-, CF3-, and Perfluoroalkyl Groups into Small Organic Molecules

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Author(s):
Kisukuri, Camila M. [1] ; Fernandes, Vitor A. [1] ; Delgado, Jose A. C. [1] ; Haering, Andreas P. [2] ; Paixao, Marcio W. [1] ; Waldvogel, Siegfried R. [2]
Total Authors: 6
Affiliation:
[1] Fed Univ Sao Carlos UFSCar Sao Carlos, Ctr Excellence Res Sustainable Chem CERSusChem, Dept Chem, BR-13565905 Sao Paulo - Brazil
[2] Johannes Gutenberg Univ Mainz, Dept Chem, Duesbergweg 10-14, D-55128 Mainz - Germany
Total Affiliations: 2
Document type: Journal article
Source: CHEMICAL RECORD; v. 21, n. 9, SI, p. 2502-2525, SEP 2021.
Web of Science Citations: 0
Abstract

Electrosynthesis can be considered a powerful and sustainable methodology for the synthesis of small organic molecules. Due to its intrinsic ability to generate highly reactive species under mild conditions by anodic oxidation or cathodic reduction, electrosynthesis is particularly interesting for otherwise challenging transformations. One such challenge is the installation of fluorinated alkyl groups, which has gained significant attention in medicinal chemistry and material science due to their unique physicochemical features. Unsurprisingly, several electrochemical fluoroalkylation methods have been established. In this review, we survey recent developments and established methods in the field of electrochemical mono-, di-, and trifluoromethylation, and perfluoroalkylation of small organic molecules. (AU)

FAPESP's process: 18/12986-1 - Development of photochemical and electrocatalytic methodologies to the synthesis and modification of heterocyclic scaffolds
Grantee:Camila de Menezes Kisukuri
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/17141-1 - Development and Mechanism Studies of New Synthetic Methodologies for the Synthesis of Bioactive Compounds.
Grantee:Ricardo Samuel Schwab
Support type: Regular Research Grants
FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support type: Research Grants - Research Centers in Engineering Program
FAPESP's process: 19/01973-9 - Exploration of the Asymmetric Induction in Ugi Variations Aiming the Stereoselective Synthesis and Functionalizationof N-Heterocycles
Grantee:Vitor Alcantara Fernandes da Silva
Support type: Scholarships in Brazil - Doctorate