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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Propolis increases Foxp(3) expression and lymphocyte proliferation in HIV-infected people: A randomized, double blind, parallel-group and placebo-controlled study

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Conte, Fernanda Lopes [1, 2] ; Tasca, Karen Ingrid [1] ; Santiago, Karina Basso [1] ; Cardoso, Eliza de Oliveira [1] ; Romagnoli, Graziela Gorete [1] ; Golim, Marjorie de Assis [2] ; Marques Braz, Aline Marcia [2] ; Berretta, Andresa Aparecida [3] ; de Souza, Lenice do Rosario [2] ; Sforcin, Jose Mauricio [1]
Total Authors: 10
[1] Sao Paulo State Univ UNESP, Inst Biosci, Campus Botucatu, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Botucatu Med Sch, Campus Botucatu, Sao Paulo - Brazil
[3] Apis Flora Indl Coml Ltda, Res Dev & Innovat Lab, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

HIV infection and the prolonged use of antiretroviral therapy (ART) contribute to persistent inflammation and immune deregulation in people living with HIV/AIDS (PLWHA). Propolis is a bee product with plenty of biological properties, including immunomodulatory and anti-inflammatory action. This work aimed to evaluate possible changes in the immune/inflammatory response in PLWHA under ART after propolis intake. Asymptomatic PLWHA were double-blindly randomized into parallel groups receiving propolis (500 mg/day, n = 20) for 3 months or placebo (n = 20). Plasma cytokines (TNF-alpha, IL-2, IL-4, IL-6, IL-10 and IL17) were evaluated by cytometric bead array; cytokine production by PBMC (IFN-gamma, IL-5, IL-17, IL-10, IL-1(i, IL-18, and IL-33) was assessed by ELISA; gene expression (T-bet, GATA-3, ROR gamma t and Foxp3) was determined by RT-qPCR, and cell proliferation was analysed by flow cytometry using CFSE staining. The average of gender, age, CD4+/CD8+ T cell count, time of diagnosis and treatment were similar in both groups. No differences were observed in cytokine levels nor in inflammasome activation. However, Pearson's correlation showed that IL-10 was directly correlated to CD4+ T cell count and inversely to IFN-gamma after treatment with propolis. Foxp3 expression and lymphocyte proliferation increased in the propolis group. Data suggested that daily propolis consumption may improve the immune response and decrease the inflammatory status in asymptomatic PLWHA under ART. (AU)

FAPESP's process: 17/14846-0 - Effect of propolis on immunological, inflammatory and oxidative stress biomarkers in people living with HIV/AIDS (PLWHA) following antiretroviral treatment
Grantee:Karen Ingrid Tasca
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/24591-6 - Evaluation of immunological, inflammatory and biochemical parameters in HIV-infected individuals under antiretroviral therapy in association with propolis
Grantee:Fernanda Lopes Conte
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/04297-1 - Influence of the propolis use on the metabolic profile of HIV-infected individuals treated with antiretroviral therapy
Grantee:Ana Claudia de Moura Moreira Alves
Support Opportunities: Scholarships in Brazil - Scientific Initiation