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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Autoantibodies neutralizing type I IFNs are present in similar to 4% of uninfected individuals over 70 years old and account for similar to 20% of COVID-19 deaths

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Author(s):
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Bastard, Paul [1, 2, 3] ; Gervais, Adrian [1, 2] ; Le Voyer, Tom [1, 2] ; Rosain, Jeremie [1, 2] ; Philippot, Quentin [1, 2] ; Manry, Jeremy [1, 2] ; Michailidis, Eleftherios [4] ; Hoffmann, Hans-Heinrich [4] ; Eto, Shohei [5] ; Garcia-Prat, Marina [6] ; Bizien, Lucy [1, 2] ; Parra-Martinez, Alba [6] ; Yang, Rui [3] ; Haljasmagi, Liis [7] ; Migaud, Melanie [1, 2] ; Sarekannu, Karita [7] ; Maslovskaja, Julia [7] ; de Prost, Nicolas [8, 9] ; Tandjaoui-Lambiotte, Yacine [10] ; Luyt, Charles-Edouard [11, 12] ; Amador-Borrero, Blanca [13] ; Gaudet, Alexandre [14, 15, 16, 17, 18] ; Poissy, Julien [14, 15, 16, 17, 18] ; Morel, Pascal [19, 20] ; Richard, Pascale [19] ; Cognasse, Fabrice [21, 22] ; Troya, Jesus [23] ; Trouillet-Assant, Sophie [24, 25, 26] ; Belot, Alexandre [24, 25, 27, 28] ; Saker, Kahina [24, 25] ; Garcon, Pierre [29] ; Riviere, Jacques G. [6] ; Lagier, Jean-Christophe [30, 31] ; Gentile, Stephanie [32, 33] ; Rosen, Lindsey B. [34] ; Shaw, Elana [34] ; Morio, Tomohiro [35] ; Tanaka, Junko [36] ; Dalmau, David [37, 38, 39] ; Tharaux, Pierre-Louis [40] ; Sene, Damien [13] ; Stepanian, Alain [41, 42] ; Megarbane, Bruno [43] ; Triantafyllia, Vasiliki [44] ; Fekkar, Arnaud [2, 45] ; Heath, James R. [46] ; Franco, Jose Luis [47] ; Anaya, Juan-Manuel [48] ; Sole-Violan, Jordi [49, 50] ; Imberti, Luisa [51] ; Biondi, Andrea [52, 53] ; Bonfanti, Paolo [54] ; Castagnoli, Riccardo [34, 55] ; Delmonte, Ottavia M. [34] ; Zhang, Yu [34, 56] ; Snow, Andrew L. [57] ; Holland, Steven M. [34] ; Biggs, Catherine M. [58] ; Moncada-Velez, Marcela [3] ; Arias, Andres Augusto [59, 3, 60] ; Lorenzo, Lazaro [1, 2] ; Boucherit, Soraya [1, 2] ; Coulibaly, Boubacar [1, 2] ; Anglicheau, Dany [61, 62] ; Planas, Anna M. [63, 64] ; Haerynck, Filomeen [65] ; Duvlis, Sotirija [66, 67] ; Nussbaum, Robert L. [68] ; Ozcelik, Tayfun [69] ; Keles, Sevgi [70] ; Bousfiha, Ahmed A. [71, 72] ; El Bakkouri, Jalila [71, 72] ; Ramirez-Santana, Carolina [47, 48] ; Paul, Stephane [73] ; Pan-Hammarstrom, Qiang [74] ; Hammarstrom, Lennart [74] ; Dupont, Annabelle [75] ; Kurolap, Alina [76] ; Metz, Christine N. [77] ; Aiuti, Alessandro [78, 79] ; Casari, Giorgio [78, 79] ; Lampasona, Vito [80] ; Ciceri, Fabio [81] ; Barreiros, Lucila A. [82] ; Dominguez-Garrido, Elena [83] ; Vidigal, Mateus [84] ; Zatz, Mayana [84] ; van de Beek, Diederik [85] ; Sahanic, Sabina [86] ; Tancevski, Ivan [86] ; Stepanovskyy, Yurii [87] ; Boyarchuk, Oksana [88] ; Nukui, Yoko [89] ; Tsumura, Miyuki [5] ; Vidaur, Loreto [90, 91] ; Tangye, Stuart G. [92, 93] ; Burrel, Sonia [94] ; Duffy, Darragh [95] ; Quintana-Murci, Lluis [96, 97] ; Klocperk, Adam [98, 99] ; Kann, Nelli Y. [100] ; Shcherbina, Anna [100] ; Lau, Yu-Lung [101] ; Leung, Daniel [101] ; Coulongeat, Matthieu [102] ; Marlet, Julien [103, 104] ; Koning, Rutger [85] ; Reyes, Luis Felipe [105, 106] ; Chauvineau-Grenier, Angelique [107] ; Venet, Fabienne [108, 109, 110] ; Monneret, Guillaume [108, 110] ; Nussenzweig, Michel C. [111, 112] ; Arrestier, Romain [8, 9] ; Boudhabhay, Idris [61, 62] ; Baris-Feldman, Hagit [113, 76] ; Hagin, David [113, 114] ; Wauters, Joost [115] ; Meyts, Isabelle [116, 117] ; Dyer, Adam H. [118, 119] ; Kennelly, Sean P. [118, 119] ; Bourke, Nollaig M. [119] ; Halwani, Rabih [120] ; Sharif-Askari, Narjes Saheb [120] ; Dorgham, Karim [121] ; Sallette, Jerome [122] ; Sedkaoui, Souad Mehlal [122] ; AlKhater, Suzan [123, 124] ; Rigo-Bonnin, Raul [125] ; Morandeira, Francisco [126] ; Roussel, Lucie [127, 128] ; Vinh, Donald C. [127, 128] ; Ostrowski, Sisse Rye [129] ; Condino-Neto, Antonio [82] ; Prando, Carolina [130] ; Bondarenko, Anastasiia [87] ; Spaan, Andras N. [131, 3] ; Gilardin, Laurent [132, 133] ; Fellay, Jacques [134, 135, 136, 137] ; Lyonnet, Stanislas [138] ; Bilguvar, Kaya [139, 140, 141, 142] ; Lifton, Richard P. [139, 140, 143] ; Mane, Shrikant [139] ; Anderson, Mark S. [144] ; Boisson, Bertrand [1, 2, 3] ; Beziat, Vivien [1, 2, 3] ; Zhang, Shen-Ying [1, 2, 3] ; Andreakos, Evangelos [44] ; Hermine, Olivier [1, 145] ; Pujol, Aurora [146, 147] ; Peterson, Part [7] ; Mogensen, Trine H. [148, 149] ; Rowen, Lee [46] ; Mond, James [150] ; Debette, Stephanie [151, 152] ; de Lamballerie, Xavier [153] ; Duval, Xavier [154, 155, 156, 157] ; Mentre, France [154, 155, 156] ; Zins, Marie [158] ; Soler-Palacin, Pere [6] ; Colobran, Roger [159] ; Gorochov, Guy [121, 160] ; Solanich, Xavier [161] ; Susen, Sophie [75] ; Martinez-Picado, Javier [162, 163, 164, 165] ; Raoult, Didier [30, 31] ; Vasse, Marc [166, 167] ; Gregersen, Peter K. [77] ; Piemonti, Lorenzo [80] ; Rodriguez-Gallego, Carlos [168, 169] ; Notarangelo, Luigi D. [34] ; Su, Helen C. [34, 170] ; Kisand, Kai [7] ; Okada, Satoshi [5] ; Puel, Anne [1, 2, 3] ; Jouanguy, Emmanuelle [1, 2, 3] ; Rice, Charles M. [4] ; Tiberghien, Pierre [19, 20] ; Zhang, Qian [1, 2, 3] ; Cobat, Aurelie [1, 2, 3] ; Abel, Laurent [1, 2, 3] ; Casanova, Jean-Laurent [112, 1, 2, 3] ; Lab, HGID ; Clinicians, COVID ; Clinicians, COVID-STORM ; Grp, NIAID Immune Response Covid ; Grp, NH-COVAIR Study ; CHGE, Danish ; Study, Danish Blood Donor ; Interest, St Jamess Hosp Sars CoV2 ; Grp, French COVID Cohort Study ; COVID-Grp, Imagine ; Consortium, Milieu Interieur ; Cohort, CoV-Contact ; Inv, Amsterdam Umc Covid-19 Biobank ; Efft, COVID Human Genetic ; Cohort, CONSTANCES ; Study, 3C-Dijon ; HealthCare, Cerba ; Grp, Etab Sang Study
Total Authors: 199
Affiliation:
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[1] Univ Paris, Imagine Inst, Paris - France
[2] Necker Hosp Sick Children, INSERM U1163, Necker Branch, Lab Human Genet Infect Dis, Paris - France
[3] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, 1230 York Ave, New York, NY 10021 - USA
[4] Rockefeller Univ, Lab Virol & Infect Dis, 1230 York Ave, New York, NY 10021 - USA
[5] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pediat, Hiroshima - Japan
[6] Univ Autonoma Barcelona UAB, Vall dHebron Res Inst, Hosp Univ Vall dHebron, Pediat Infect Dis & Immunodeficiencies Unit, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia - Spain
[7] Univ Tartu, Inst Biomed & Translat Med, Tartu - Estonia
[8] Hop Univ Henri Mondor, Assistance Publ Hop Paris AP HP, Serv Med Intens Reanimat, Paris - France
[9] Univ Paris Est Creteil, Fac Sante Creteil, Grp Rech Clin CARMAS, 51 Ave Marechal de Lattre de Tassigny, F-94010 Creteil - France
[10] Avicenne Hosp, AP HP, INSERM U1272, Hypoxia & Lung, Bobigny - France
[11] Sorbonne Univ, Hop Pitie Salpetriere, AP HP, Med Intens Reanimat, Paris - France
[12] INSERM UMRS 1166 iCAN, Inst Cardiometab & Nutr, Paris - France
[13] Paris Univ, Lariboisiere Hosp, AP HP, Internal Med Dept, Paris - France
[14] Inst Pasteur, Lille - France
[15] Univ Lille, U1019 UMR9017, Ctr Infect & Immun Lille, Lille - France
[16] CNRS, UMR9017, Lille - France
[17] INSERM U1019, Lille - France
[18] CHU Lille, Pole Reanimat, Hop Roger Salengro Lille, Lille - France
[19] Etab Francais Sang, La Plaine St Denis - France
[20] Univ Franche Comte, EFS, INSERM, UMR1098 RIGHT, Besancon - France
[21] Univ Jean Monnet St Etienne, Univ Lyon, SAINBIOSE, INSERM U1059, St Etienne - France
[22] Etab Francais Sang, St Etienne - France
[23] Infanta Leonor Univ Hosp, Dept Internal Med, Madrid - Spain
[24] Hosp Civils Lyon, Lyon - France
[25] Lyon Univ, Int Ctr Res Infectiol, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon - France
[26] Lyon Sud Hosp, Hosp Civils Lyon, Hosp Civils Lyon BioMerieux, Joint Res Unit, Pierre Benite - France
[27] Natl Referee Ctr Rheumat & Autoimmune & Syst Dis, Lyon - France
[28] Hosp Civils Lyon, Immunopathol Federat LIFE, Lyon - France
[29] Grand Hop Est Francilien, Site Marne La Vallee, Intens Care Unit, Jossigny - France
[30] Inst Hosp Univ Mediterranee Infect, Marseille - France
[31] Aix Marseille Univ, IRD, Assistance Publ Hop Marseille APHM, MEPHI, Marseille - France
[32] Hop Univ Marseille, AP HM, Serv Evaluat Med, Marseille - France
[33] Aix Marseille Univ, Sch Med, EA 3279, CEReSS Hlth Serv Res & Qual Life Ctr, La Timone Med Campus, Marseille - France
[34] NIAID, Lab Clin Immunol & Microbiol, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 - USA
[35] Tokyo Med & Dent Univ TMDU, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Tokyo - Japan
[36] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Epidemiol Infect Dis Control & Prevent, Hiroshima - Japan
[37] Univ Barcelona, Barcelona - Spain
[38] Hosp Univ Mutua Terrassa, Terrassa - Spain
[39] Fundacio Docencia & Recerca MutuaTerrassa, Terrassa - Spain
[40] Univ Paris, Paris Cardiovasc Res Ctr, PARCC, INSERM, Paris - France
[41] Univ Paris Diderot, Hop Lariboisiere, AP HP, Serv Hematol Biol, Paris - France
[42] Univ Paris Diderot, Inst Univ Hematol Hop St Louis, EA3518, Paris - France
[43] Univ Paris Diderot, Hop Lariboisiere, AP HP, Reanimat Med & Toxicol, INSERM, Unite Mixte Rech Sc, Paris - France
[44] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Lab Immunobiol, Athens 11527 - Greece
[45] Grp Hosp Pitie Salpetriere, AP HP, Serv Parasitol Mycol, Paris - France
[46] Inst Syst Biol, Seattle, WA - USA
[47] Univ Antioquia UdeA, Sch Med, Dept Microbiol & Parasitol, Primary Immunodeficiencies Grp, Medellin - Colombia
[48] Univ Rosario, Sch Med & Hlth Sci, Ctr Autoimmune Dis Res, Bogota - Colombia
[49] Univ Hosp Gran Canaria Dr Negrin, Canarian Hlth Syst, Intens Care Med, Las Palmas Gran Canaria, Canary Islands - Spain
[50] Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid - Spain
[51] ASST Spedali Civili Brescia, Diagnost Dept, CREA Lab, Brescia - Italy
[52] Univ Milano Bicocca, Fdn MBBM, Osped San Gerardo, EuroBloodNet, MetabERN, Pediat Dept, Monza - Italy
[53] Univ Milano Bicocca, Fdn MBBM, Osped San Gerardo, EuroBloodNet, MetabERN, Ctr Tettamanti European Reference Network PaedCan, Monza - Italy
[54] Univ Milano Bicocca, San Gerardo Hosp, Dept Infect Dis, Monza - Italy
[55] Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pavia - Italy
[56] NIAID, Clin Genom Program, NIH, 9000 Rockville Pike, Bethesda, MD 20892 - USA
[57] Uniformed Serv Univ Hlth Sci, Dept Pharmacol & Mol Therapeut, Bethesda, MD 20814 - USA
[58] Univ British Columbia, British Columbia Childrens Hosp, Dept Pediat, Vancouver, BC - Canada
[59] Univ Antioquia UdeA, Sch Microbiol, Medellin - Colombia
[60] Univ Antioquia UdeA, Primary Immunodeficiencies Grp, Medellin - Colombia
[61] Necker Univ Hosp, AP HP, Dept Nephrol & Transplantat, Paris - France
[62] Paris Univ, INSERM U1151 CNRS UMR 8253, INEM, Paris - France
[63] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona - Spain
[64] CSIC, Inst Biomed Res IIBB, Barcelona - Spain
[65] Ghent Univ Hosp, Ctr Primary Immunodeficiency Ghent, Jeffrey Modell Diag & Res Ctr, Dept Paediat Immunol & Pulmonol, Ghent - Belgium
[66] Univ Goce Delchev, Fac Med Sci, Stip - North Macedonia
[67] Inst Publ Hlth Republ North Macedonia, Skopje - North Macedonia
[68] Univ Calif San Francisco, Canc Genet & Prevent Program, San Francisco, CA 94143 - USA
[69] Bilkent Univ, Dept Mol Biol & Genet, Ankara - Turkey
[70] Necmettin Erbakan Univ, Meram Fac Med, Konya - Turkey
[71] Hassan II Univ, CHU Ibn Rushd, Dept Pediat Infect Dis, Clin Immunol Unit, Casablanca - Morocco
[72] Hassan II Univ, Fac Med & Pharm, Lab Immunol Clin Inflammat & Allergie, LICIA, Casablanca - Morocco
[73] Univ Hosp St Etienne, GIMAP Ctr Int Rech Infectiol CIRI INSERM U1111, CIC1408, Dept Immunol, St Etienne - France
[74] Karolinska Inst, Dept Biosci & Nutr, Stockholm - Sweden
[75] Univ Lille, INSERM, CHU Lille, Inst Pasteur Lille, U1011 EGID, F-59000 Lille - France
[76] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Genet Inst, Tel Aviv - Israel
[77] Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY - USA
[78] Univ Vita Salute San Raffaele, Milan - Italy
[79] IRCCS Osped San Raffaele, Clin Genom, Milan - Italy
[80] IRCCS San Raffaele Sci Inst, Diabet Res Inst, Milan - Italy
[81] IRCCS San Raffaele Sci Inst, Hematol & Bone Marrow Transplantat Unit, Milan - Italy
[82] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
[83] Ctr Invest Biomed La Rioja, Fdn Rioja Salud, Logrono - Spain
[84] Univ Sao Paulo, Sao Paulo - Brazil
[85] Amsterdam Neurosci, Dept Neurol, Amsterdam - Netherlands
[86] Med Univ Innsbruck, Dept Internal Med 2, Innsbruck - Austria
[87] Shupyk Natl Healthcare Univ Ukraine, Kiev - Ukraine
[88] I Horbachevsky Ternopil Natl Med Univ, Dept Childrens Dis & Pediat Surg, Ternopol - Ukraine
[89] TMDU, Med Hosp, Dept Infect Control & Prevent, Tokyo - Japan
[90] Inst Salud Carlos III, CIBERES, Madrid - Spain
[91] Donostia Univ Hosp, Biodonostia Inst Donostia, Intens Care Med, San Sebastian - Spain
[92] Garvan Inst Med Res, Sydney, NSW - Australia
[93] UNSW Sydney, Fac Med & Hlth, St Vincents Clin Sch, Sydney, NSW - Australia
[94] Sorbonne Univ, INSERM U1136, Inst Pierre Louis Epidemiol & Sante Publ iPLESP, Hop Pitie Salpetriere, AP HP, Serv Virol, Paris - France
[95] Inst Pasteur, Translat Immunol Lab, Paris - France
[96] Inst Pasteur, Human Evolutionary Genet Unit, CNRS UMR 2000, Paris - France
[97] Coll France, Chair Human Genom & Evolut, Paris - France
[98] Univ Hosp Motol, Prague - Czech Republic
[99] Charles Univ Prague, Fac Med 2, Dept Immunol, Prague - Czech Republic
[100] Dmitry Rogachev Natl Med Res Ctr Pediat Hematol O, Moscow - Russia
[101] Univ Hong Kong, Dept Paediat & Adolescent Med, Hong Kong - Peoples R China
[102] Tours Univ Med Ctr, Div Geriatr Med, Tours - France
[103] Univ Tours, MAVIVH, INSERM U1259, Tours - France
[104] CHU Tours, Serv Bacteriol Virol & Hyg Hosp, Tours - France
[105] Univ La Sabana, Dept Microbiol, Chia - Colombia
[106] Clin Univ La Sabana, Dept Crit Care Med, Chia - Colombia
[107] CHI Robert Ballanger, Serv Biol Med, Aulnay Sous Bois - France
[108] Hosp Civils Lyon, Lab Immunol, Hop Edouard Herriot, Lyon - France
[109] Univ Claude Bernard Lyon 1, Ecole Normale Super Lyon, UMR5308, CIRI, INSERM U1111, CNRS, Lyon - France
[110] Univ Claude Bernard Lyon 1, Hosp Civils Lyon, Hop Edouard Herriot BioMerieux, EA 7426, Pathophysiol Injury Induced Immunosuppres, Lyon - France
[111] Rockefeller Univ, Lab Mol Immunol, 1230 York Ave, New York, NY 10021 - USA
[112] Howard Hughes Med Inst, New York, NY 10065 - USA
[113] Tel Aviv Univ, Sackler Fac Med, Tel Aviv - Israel
[114] Tel Aviv Sourasky Med Ctr, Dept Med, Allergy & Clin Immunol Unit, Tel Aviv - Israel
[115] Univ Hosp Leuven, Med Intens Care Unit, Leuven - Belgium
[116] Katholieke Univ Leuven, Lab Inborn Errors Immun, Dept Microbiol Immunol & Transplantat, Leuven - Belgium
[117] Univ Hosp Leuven, Jeffrey Modell Diagnost & Res Network Ctr, Dept Pediat, Leuven - Belgium
[118] Tallaght Univ Hosp, Dept Age Related Healthcare, Dublin - Ireland
[119] Trinity Coll Dublin, Sch Med, Dept Med Gerontol, Dublin - Ireland
[120] Univ Sharjah, Coll Med, Sharjah Inst Med Res, Sharjah - U Arab Emirates
[121] Sorbonne Univ, Ctr Immunol & Malad Infect, CIMI Paris, INSERM, Paris - France
[122] Cerba HealthCare, Issy Les Moulineaux - France
[123] King Fahad Hosp Univ, Dept Pediat, Al Khobar - Saudi Arabia
[124] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dammam - Saudi Arabia
[125] Hosp Univ Bellvitge, Dept Clin Lab, IDIBELL, Barcelona - Spain
[126] Hosp Univ Bellvitge, Dept Immunol, IDIBELL, Barcelona - Spain
[127] McGill Univ Hlth Ctr, Dept Med, Div Infect Dis, Montreal, PQ - Canada
[128] McGill Univ Hlth Ctr, Res Inst, Infect Dis Susceptibil Program, Montreal, PQ - Canada
[129] Copenhagen Univ Hosp, Rishosp, Dept Clin Immunol, Copenhagen - Denmark
[130] Inst Pesquisa Pele Pequeno Principe, Fac Pequeno Principe, Curitiba, Parana - Brazil
[131] Univ Med Ctr Utrecht, Dept Med Microbiol, Utrecht - Netherlands
[132] Hop Univ Jean Verdier, AP HP, Serv Med Interne, Bondy - France
[133] Ctr Rech Cordeliers, INSERM U1138, Paris - France
[134] Swiss Inst Bioinformat, Lausanne - Switzerland
[135] Univ Lausanne, Lausanne - Switzerland
[136] Ecole Polytech Fed Lausanne, Sch Life Sci, Lausanne - Switzerland
[137] Lausanne Univ Hosp, Precis Med Unit, Lausanne - Switzerland
[138] Univ Paris, Imagine Inst, INSERM UMR 1163, Paris - France
[139] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 - USA
[140] Yale Sch Med, Yale Ctr Genome Anal, New Haven, CT - USA
[141] Yale Univ, Dept Neurosurg, Sch Med, New Haven, CT - USA
[142] Acibadem Univ, Dept Med Genet, Sch Med, Istanbul - Turkey
[143] Rockefeller Univ, Lab Human Genet & Genom, 1230 York Ave, New York, NY 10021 - USA
[144] Univ Calif San Francisco, Diabet Ctr, San Francisco, CA 94143 - USA
[145] Hop Necker Enfants Malad, AP HP, Dept Hematol, Paris - France
[146] Catalan Inst Res & Adv Studies ICREA, Barcelona - Spain
[147] Hosp Duran & Reynals, IDIBELL, Neurometab Dis Lab, CIBERER U759, Barcelona - Spain
[148] Aarhus Univ, Dept Biomed, Aarhus - Denmark
[149] Aarhus Univ Hosp, Dept Infect Dis, Aarhus - Denmark
[150] ADMA Biol Inc, Ramsey, NJ - USA
[151] Univ Bordeaux, Bordeaux Populat Hlth Ctr, UMR1219, INSERM, F-33000 Bordeaux - France
[152] Bordeaux Univ Hosp, Inst Neurodegenerat Dis, Dept Neurol, F-33000 Bordeaux - France
[153] UVE Aix Marseille Univ, Unite Virus Emergents, IHU Mediterranee Infect, IRD 190, INSERM 1207, Marseille - France
[154] INSERM CIC 1425, Paris - France
[155] Univ Paris, INSERM, IAME UMR S 1137, Paris - France
[156] Hop Bichat Claude Bernard, AP HP, Dept Epidemiol Biostat & Rech Clin, Paris - France
[157] Bichat Claude Bernard Hosp, AP HP, Infect & Trop Dis Dept, Paris - France
[158] Univ Paris, Univ Paris Saclay, INSERM UMS11, UVSQ, Villejuif - France
[159] Hosp Univ Vall dHebron, Vall dHebron Res Inst, Genet Dept, Immunol Div, Vall dHebron Barcelona Hosp Campus, Barcelona, Catalonia - Spain
[160] Hop La Pitie Salpetriere, AP HP, Dept Immunol, Paris - France
[161] Hosp Univ Bellvitge, Dept Internal Med, IDIBELL, Barcelona - Spain
[162] IrsiCaixa AIDS Res Inst, Badalona - Spain
[163] Inst Hlth Sci Res Germans Trias & Pujol IGTP, Badalona - Spain
[164] Univ Vic Cent Univ Catalonia UVic UCC, Fac Med, Ctr Hlth & Social Care Res CESS, Infect Dis & Immun, Vic - Spain
[165] Catalan ICREA, Barcelona - Spain
[166] Hop Foch, Serv Biol Clin, Suresnes - France
[167] Hop Foch, UMR S 1176, Suresnes - France
[168] Univ Hosp Gran Canaria Dr Negrin, Canarian Hlth Syst, Dept Immunol, Las Palmas Gran Canaria - Spain
[169] Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria - Spain
[170] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA - USA
Total Affiliations: 170
Document type: Journal article
Source: SCIENCE IMMUNOLOGY; v. 6, n. 62 AUG 2021.
Web of Science Citations: 7
Abstract

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-alpha and/or IFN-omega are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-alpha and/or IFN-omega (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-beta. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-alpha and/or IFN-omega are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-beta do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. (AU)

FAPESP's process: 20/09702-1 - Study of protective genetic variants in resilient nonagenarians and centenarians
Grantee:Mateus Vidigal de Castro
Support type: Scholarships in Brazil - Post-Doctorate