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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular Networking Discloses the Chemical Diversity of Flavonoids and Selaginellins in Selaginella convoluta

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Santos Reginaldo, Fernanda Priscila [1] ; Pires Bueno, Paula Carolina [2, 3] ; de Matos Costa, Isabelly Cristina [1] ; Roque, Alan de Araujo [4] ; Fett-Neto, Arthur Germano [5, 6] ; Cavalheiro, Alberto Jose [7] ; Giordani, Raquel Brandt [1]
Total Authors: 7
[1] Fed Univ Rio Grande do Norte UFRN, Dept Pharm, Gal Gustavo Cordeiro de Farias St S-N, BR-59012570 Natal, RN - Brazil
[2] Max Planck Inst Mol Plant Physiol, Potsdam - Germany
[3] Univ Sao Paulo FCFRP USP, Fac Pharmaceut Sci Ribeirao Preto, Ribeirao Preto, SP - Brazil
[4] Dunas Pk Herbarium, Inst Sustainable Dev & Environm, Natal, RN - Brazil
[5] Fed Univ Rio Grande do Sul UFRGS, Ctr Biotechnol, Lab Plant Physiol, Porto Alegre, RS - Brazil
[6] Fed Univ Rio Grande do Sul UFRGS, Dept Bot, Porto Alegre, RS - Brazil
[7] Sao Paulo State Univ UNESP, Inst Chem, Araraquara, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Planta Medica; v. 87, n. 01/02, p. 113-123, FEB 2021.
Web of Science Citations: 0

Selaginella convoluta is a desiccation tolerant plant native to the Brazilian semiarid region (Caatinga), endowed with an effective drought resistance mechanism. As part of our research efforts to understand the chemical diversity of S. convoluta, dehydrated (harvested in their natural habitat in the dry season) and hydrated (plant acclimated in a laboratory after rehydration) specimens were analyzed by HR-LC-ESI-MS/MS followed by a structural annotation on the Global Natural Products Social Molecular Networking Web platform. The molecular networking approach allowed for putative annotation of 39 metabolites, mainly selaginellins and flavonoids. Based on MS/MS data, three unprecedented selaginellins were annotated: 29-hydroxy selaginellin O, 29-hydroxy selaginellin A, and 4-[{[}2-(4-hydrophenyl)-6-{[}2-(4-hydroxyphenyl)ethynyl]phenyl](4-oxocy clohexa-2,5-dien-1-ylidene)methyl]benzaldehyde. Th results pointed out that valuable scientific knowledge can be obtained from studies conducted with plants in their natural habitat by allowing a more realistic profile of chemical diversity. The present study adds new information on specialized metabolites of S. convoluta , mainly flavonoids and selaginellins, and highlights the species as an untapped source of chemobiodiversity from Caatinga. (AU)

FAPESP's process: 14/50926-0 - INCT 2014: biodiversity and natural products
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 19/08477-7 - Integrated metabolism analysis for Glycine max responses to water stress
Grantee:Paula Carolina Pires Bueno
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 17/19702-6 - Integrated omics approaches for the evaluation of the micromolecular phenotypic dynamics of Glycine max (soja) genetically modified for water stress tolerance
Grantee:Paula Carolina Pires Bueno
Support Opportunities: Scholarships in Brazil - Post-Doctoral