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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Are cachexia-associated tumors transmitTERS of ER stress?

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Author(s):
Yamagata, Ana Sayuri [1] ; Freire, Paula Paccielli [2]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: BIOCHEMICAL SOCIETY TRANSACTIONS; v. 49, n. 4, p. 1841-1853, AUG 2021.
Web of Science Citations: 1
Abstract

Cancer cachexia is associated with deficient response to chemotherapy. On the other hand, the tumors of cachectic patients remarkably express more chemokines and have higher immune infiltration. For immunogenicity, a strong induction of the unfolded protein response (UPR) is necessary. UPR followed by cell surface exposure of calreticulin on the dying tumor cell is essential for its engulfment by macrophages and dendritic cells. However, some tumor cells upon endoplasmic reticulum (ER) stress can release factors that induce ER stress to other cells, in the so-called transmissible ER stress (TERS). The cells that received TERS produce more interleukin 6 (IL-6) and chemokines and acquire resistance to subsequent ER stress, nutrient deprivation, and genotoxic stress. Since ER stress enhances the release of extracellular vesicles (EVs), we suggest they can mediate TERS. It was found that ER stressed cachexia-inducing tumor cells transmit factors that trigger ER stress in other cells. Therefore, considering the role of EVs in cancer cachexia, the release of exosomes can possibly play a role in the process of blunting the immunogenicity of the cachexia-associated tumors. We propose that TERS can cause an inflammatory and immunosuppressive phenotype in cachexia-inducing tumors. (AU)

FAPESP's process: 12/11666-7 - Gene expression kinetics of muscle-specific micro-RNAs miR-208 and miR-499 in cells treated in vitro with TNF-alpha and INF-gamma
Grantee:Paula Paccielli Freire
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 20/00086-6 - Proteostasis in the adipose tissue of Cachectic Cancer patients
Grantee:Ana Sayuri Yamagata
Support type: Scholarships in Brazil - Doctorate (Direct)