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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exploring the use of upconversion nanoparticles in chemical and biological sensors: from surface modifications to point-of-care devices

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Arai, Marylyn S. [1] ; de Camargo, Andrea S. S. [1]
Total Authors: 2
[1] Univ Sao Paulo, Sao Carlos Inst Phys, Av Trabalhador Saocarlense 400, BR-13566590 Sao Carlos - Brazil
Total Affiliations: 1
Document type: Review article
Source: NANOSCALE ADVANCES; v. 3, n. 18 JUL 2021.
Web of Science Citations: 0

Upconversion nanoparticles (UCNPs) have emerged as promising luminescent nanomaterials due to their unique features that allow the overcoming of several problems associated with conventional fluorescent probes. Although UCNPs have been used in a broad range of applications, it is probably in the field of sensing where they best evidence their potential. UCNP-based sensors have been designed with high sensitivity and selectivity, for detection and quantification of multiple analytes ranging from metal ions to biomolecules. In this review, we deeply explore the use of UCNPs in sensing systems emphasizing the most relevant and recent studies on the topic and explaining how these platforms are constructed. Before diving into UCNP-based sensing platforms it is important to understand the unique characteristics of these nanoparticles, why they are attracting so much attention, and the most significant interactions occurring between UCNPs and additional probes. These points are covered over the first two sections of the article and then we explore the types of fluorescent responses, the possible analytes, and the UCNPs' integration with various material types such as gold nanostructures, quantum dots and dyes. All the topics are supported by analysis of recently reported sensors, focusing on how they are built, the materials' interactions, the involved synthesis and functionalization mechanisms, and the conjugation strategies. Finally, we explore the use of UCNPs in paper-based sensors and how these platforms are paving the way for the development of new point-of-care devices. (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 19/12588-9 - Optical biosensors for the fast detection of pathogenic bacteria
Grantee:Marylyn Setsuko Arai
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 21/01170-3 - Glassy and ceramic multifunctional luminescent nanosystems for applications in thermometry and oximetry
Grantee:Pedro Felipe Garcia Martins da Costa
Support type: Scholarships in Brazil - Doctorate