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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Parasitic sirtuin 2 as an opportunity in drug discovery

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Gomes, Renan Augusto [1] ; Fornari, Evelin [1] ; Silva Rocha, Ana Carolina [1] ; Tripodi, Gustavo Luis [1] ; da Silva Emery, Flavio [2] ; Goulart Trossini, Gustavo Henrique [1]
Total Authors: 6
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, Av Lineu Prestes, 580, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, Av Cafe, S-N, BR-14040903 Ribeirao Preto - Brazil
Total Affiliations: 2
Document type: Review article
Source: Future Medicinal Chemistry; v. 13, n. 16, p. 1397-1409, AUG 2021.
Web of Science Citations: 0

Infections caused by protozoans remain a public health issue, especially in tropical countries. Serious adverse events, lack of efficacy at the different stages of the infection and routes of administration that have a negative impact on treatment adherence are some of the problems with currently available therapy against these diseases. Here we describe an epigenetic target, sirtuin 2 and its related proteins, that is promising given the results in phenotypic assays and in vivo models against Sir2 of Plasmodium falciparum, Leishmania donovani, Leishmania infantum, Schistosoma mansoni, Trypanosoma brucei and Trypanosoma cruzi parasites. The results we present highlight how this target can be extensively explored and how its inhibitors might be employed in the clinic. (AU)

FAPESP's process: 17/06568-0 - Immunization of LDLr - / - mice with electronegative LDL mimetic peptides: a potential therapeutic strategy for atherosclerosis
Grantee:Gustavo Luis Tripodi
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/15650-0 - Application of Structure-Based Drug Design in parasite cysteine protease inhibitor search (cruzain (T. cruzi and CPB (Leishmanioses))
Grantee:Drielli Gomes Vital Fujii
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/25543-8 - Medicinal Chemistry strategies (LBDD and SBDD) in the search of tripanomatides sirtuin 2 inhibitors
Grantee:Gustavo Henrique Goulart Trossini
Support type: Regular Research Grants