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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development of poly(epsilon-polycaprolactone)/hydroxyapatite composites for bone tissue regeneration

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Backes, Eduardo Henrique [1] ; Beatrice, Cesar Augusto Goncalves [1] ; Shimomura, Kawany Munique Boriolo [2] ; Harb, Samarah Vargas [1] ; Pachane, Bianca Cruz [3] ; Selistre-de-Araujo, Heloisa Sobreiro ; Costa, Lidiane Cristina [1] ; Passador, Fabio Roberto ; Pessan, Luiz Antonio [1, 4]
Total Authors: 9
[1] Univ Fed Sao Carlos, Grad Program Mat Sci & Engn, Mat Engn Dept, Via Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Mat Engn Dept, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Fed Sao Carlos, Lab Biochem & Mol Biol, Dept Physiol Sci, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[4] Univ Fed Sao Carlos, Inst Sci & Technol, Rua Talim 330, BR-12231280 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Materials Research; v. 36, n. 15, SI AUG 2021.
Web of Science Citations: 0

The incorporation of osteoconductive hydroxyapatite (HA) into poly(sigma-polycaprolactone) (PCL) may enhance the material hydrophilicity, protein adsorption, roughness, and consequently, bone formation. In this work, PCL/HA composites with 5, 10, and 25 wt% of HA were prepared by melt compounding followed by hot compression, and their properties such as torque, molecular weight, mechanical resistance, and viscosity were compared to neat PCL to understand the influence of the filler on the polymer stability and printability. The addition of 5 and 10 wt% of HA leads to properties similar to the neat PCL; therefore, these compositions were chosen to produce scaffolds by 3D printing. The scaffolds presented excellent printability and homogenous dispersion of the HA. The compressive strength modulus of both compressed samples and scaffolds is around 30 MPa, similar to cancellous bone. The presence of increasing HA content combined with surface treatment using NaOH enhanced osteoblast proliferation. (AU)

FAPESP's process: 11/21313-1 - Study of the reaction kinetic and the addition of the metal deactivators in the grafting of maleic anhydride onto polypropylene in the presence and absence of the nanoparticles
Grantee:Silvia Helena Prado Bettini
Support type: Regular Research Grants
FAPESP's process: 17/09609-9 - Development of bioinspired scaffolds of PLA/bioactive ceramic fillers through 3D printing
Grantee:Luiz Antonio Pessan
Support type: Regular Research Grants
FAPESP's process: 18/14151-4 - Development and characterization of bioactive PCL/TCP composites
Grantee:Kawany Munique Boriolo Shimomura
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/11366-7 - Development of bio-inspired PLA/bioglass scaffolds via 3D printed
Grantee:Eduardo Henrique Backes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/26060-3 - Bioactive and bactericidal scaffolds for bone regeneration via 3D printing
Grantee:Samarah Vargas Harb
Support type: Scholarships in Brazil - Post-Doctorate