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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Determination of the Elemental Composition of Ayahuasca and Assessments Concerning Consumer Safety

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Guimaraes, Ivanilce Cristina [1] ; Tofoli, Luis Fernando [2] ; Sussulini, Alessandra [1, 3]
Total Authors: 3
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Lab Bioanalyt & Integrated Omics LaBIOm, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Interdisciplinary Cooperat Ayahuasca Res & Outrea, UNICAMP, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Natl Inst Sci & Technol Bioanalyt INCTBio, Inst Chem, UNICAMP, POB 6154, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BIOLOGICAL TRACE ELEMENT RESEARCH; v. 199, n. 3, p. 1179-1184, MAR 2021.
Web of Science Citations: 2

The consumption of ayahuasca, a brew prepared from the decoction of two Amazon plants, has increased worldwide in the last decades. This fact raised questions about the safety in its oral administration. In this sense, information concerning the chemical composition of ayahuasca is essential to find a comprehensive reply. Therefore, the aim of this study consisted of determining the elemental composition of ready-to-consume ayahuasca samples produced in Brazil, in order to evaluate the safety in the oral administration of this beverage, considering recommended macroelement and microelement daily intake values and the permitted limits of potentially toxic heavy metals. Real ayahuasca samples, obtained from Brazilian religious groups, underwent microwave radiation-assisted acid decomposition, and Li, Al, Mn, Fe, Co, Cu, Zn, As, Cd, Hg, and Pb concentrations were determined by ICP-MS, while Ca, Mg, K, and P concentrations were determined by ICP OES. Method accuracy was assessed by analyte addition and recovery assays. Recoveries ranged from 80 and 118%, indicating satisfactory accuracy. Limit of detection (LOD) and limit of quantification (LOQ) values were lower than 1 mg L-1 for the macroelements determined by ICP OES and lower than 3.5 mu g L-1 for the microelements determined by ICP-MS. The concentrations of the elements determined in the samples were lower than the recommended or tolerable limits; hence, it is possible to affirm that ayahuasca presents safe administration levels regarding total elemental content. (AU)

FAPESP's process: 18/01525-3 - Metabolomic studies of depression patients treated with ayahuasca
Grantee:Alessandra Sussulini
Support type: Regular Research Grants
FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Lauro Tatsuo Kubota
Support type: Research Projects - Thematic Grants