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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Curcumin encapsulation in nanostructures for cancer therapy: A 10-year overview

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Author(s):
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D'Angelo, Natalia A. [1] ; Noronha, Mariana A. [1] ; Kurnik, Isabelle S. [2] ; Camara, Mayra C. C. [1] ; Vieira, Jorge M. [3] ; Abrunhosa, Luis [3] ; Martins, Joana T. [3] ; Alves, Thais F. R. [4, 5, 6] ; Tundisi, Louise L. [1] ; Ataide, Janaina A. [1] ; Costa, Juliana S. R. [1] ; Jozala, Angela F. [7] ; Nascimento, Laura O. [1] ; Mazzola, Priscila G. [1] ; Chaud, V, Marco ; Vicente, Antonio A. [3] ; Lopes, Andre M. [1]
Total Authors: 17
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Fac Pharmaceut Sci, Campinas - Brazil
[2] Sao Paulo State Univ, UNESP, Sch Pharmaceut Sci, Araraquara, SP - Brazil
[3] Univ Minho, Ctr Biol Engn CEB, Braga - Portugal
[4] V, Univ Sorocaba, Lab Biomat & Nanotechnol LaBNUS, Sorocaba - Brazil
[5] V, Univ Sorocaba, Coll Engn Bioproc & Biotechnol, Sorocaba - Brazil
[6] V, Sorocaba Technol Pk, Sorocaba Dev & Innovat Agcy INOVA Sorocaba, Sorocaba - Brazil
[7] Univ Sorocaba, Lab Ind Microbiol & Fermentat Proc LAMINFE, Sorocaba - Brazil
Total Affiliations: 7
Document type: Review article
Source: International Journal of Pharmaceutics; v. 604, JUL 15 2021.
Web of Science Citations: 2
Abstract

Curcumin (CUR) is a phenolic compound present in some herbs, including Curcuma longa Linn. (turmeric rhizome), with a high bioactive capacity and characteristic yellow color. It is mainly used as a spice, although it has been found that CUR has interesting pharmaceutical properties, acting as a natural antioxidant, antiinflammatory, antimicrobial, and antitumoral agent. Nonetheless, CUR is a hydrophobic compound with low water solubility, poor chemical stability, and fast metabolism, limiting its use as a pharmacological compound. Smart drug delivery systems (DDS) have been used to overcome its low bioavailability and improve its stability. The current work overviews the literature from the past 10 years on the encapsulation of CUR in nanostructured systems, such as micelles, liposomes, niosomes, nanoemulsions, hydrogels, and nanocomplexes, emphasizing its use and ability in cancer therapy. The studies highlighted in this review have shown that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages. (AU)

FAPESP's process: 18/10799-0 - Combinatorial therapy using polymersomes decorated with transferrin and incorporated into chitosan hydrogels as smart drug delivery systems for melanoma tumor cells
Grantee:André Moreni Lopes
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 18/07707-6 - Development of formulation for burns: analgesia, infection control and healing
Grantee:Priscila Gava Mazzola
Support Opportunities: Regular Research Grants
FAPESP's process: 18/06475-4 - Development of pharmaceutical formulation for burns' healing
Grantee:Janaína Artem Ataide
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/10789-1 - Combinatorial therapy using polymersomes decorated with transferrin and incorporated into chitosan hydrogels as smart drug delivery systems for melanoma tumor cells
Grantee:André Moreni Lopes
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/08549-8 - Polymersomes decorated with transferrin and evaluation of their stability and drug release behavior
Grantee:Mayra Caroline Cunha Câmara
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 20/03727-2 - Polymersomes development aiming at the co-encapsulation of drugs for application in cancer therapy
Grantee:Natalia Aimee D'Angelo
Support Opportunities: Scholarships in Brazil - Master