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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serological and molecular epidemiology of the Dengue, Zika and Chikungunya viruses in a risk area in Brazil

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Mota, Magaly Lima [1, 2] ; dos Santos Souza Marinho, Robson [3] ; Duro, Rodrigo Lopes Sanz [3] ; Hunter, James [3] ; de Menezes, Irwin Rose Alencar [4] ; de Lima Silva, Joao Marcos Ferreira [2] ; Pereira, Glaubervanio Leite Tavares [2] ; Sabino, Ester Cerdeira [5] ; Grumach, Anete [1] ; Diaz, Ricardo Sobhie [3] ; do Socorro Lucena, Maria [6] ; Komninakis, Shirley Vasconcelos [1, 3]
Total Authors: 12
[1] ABC, Fac Med, BR-09060870 Santo Andre, SP - Brazil
[2] Ctr Univ Dr Leao Sampaio, BR-63040405 Juazeiro Do Norte - Brazil
[3] Univ Fed Sao Paulo, Retrovirol Lab, BR-04039032 Sao Paulo, SP - Brazil
[4] Univ Reg Cariri, BR-63105010 Crato, CE - Brazil
[5] Univ Sao Paulo, Inst Trop Med, BR-05403000 Sao Paulo, SP - Brazil
[6] Cent Publ Hlth Lab, BR-63010464 Juazeiro Do Norte, CE - Brazil
Total Affiliations: 6
Document type: Journal article
Source: BMC INFECTIOUS DISEASES; v. 21, n. 1 JUL 24 2021.
Web of Science Citations: 0

Background The co-circulation of types of arbovirus in areas where they are endemic increased the risk of outbreaks and limited the diagnostic methods available. Here, we analyze the epidemiological profile of DENV, CHIKV and ZIKV at the serological and molecular level in patients with suspected infection with these arboviruses in the city of Juazeiro do Norte, Ceara, Brazil. Methods In 2016, the Central Public Health Laboratory (LACEN) of Juazeiro do Norte received 182 plasma samples from patients who visited health facilities with symptoms compatible with arbovirus infection. The LACEN performed serological tests for detection of IgM/IgG to DENV and CHIKV. They then sent these samples to the Retrovirology Laboratory of the Federal University of Sao Paulo and Faculty of Medical of the ABC where molecular analyses to confirm the infection by DENV, ZIKV and CHIKV were performed. The prevalence of IgM/IgG antibodies and of infections confirmed by RT-qPCR were presented with 95% confidence interval. Results In serologic analysis, 125 samples were positive for antibodies against CHIKV and all were positive for antibodies against DENV. A higher prevalence of IgG against CHIKV (63.20% with 95% CI: 45.76-70.56) than against DENV (95.05% with 95% CI: 78.09-98.12) was observed. When the samples were submitted to analysis by RT-qPCR, we observed the following prevalence: mono-infection by ZIKV of 19.23% (95% CI: 14.29-34.82) patients, mono-infection by CHIKV of 3.84% (95% CI: 2.01-5.44) and co-infection with ZIKV and CHIKV of 1.09% (95% CI: 0.89-4.56). Conclusion The serologic and molecular tests performed in this study were effective in analyzing the epidemiological profile of DENV, CHIKV and ZIKV in patients with suspected infection by these arboviruses in the city of Juazeiro do Norte, Ceara/Brazil. (AU)

FAPESP's process: 15/19343-0 - Viral metagenomics in individuals with HIV/AIDS late diagnosis
Grantee:Shirley Cavalcante Vasconcelos
Support Opportunities: Regular Research Grants