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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dopamine D2 receptors in the expression and extinction of contextual and cued conditioned fear in rats

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de Vita, Vivian M. [1] ; Zapparoli, Heloisa R. [1] ; Reimer, Adriano E. [2, 1, 3] ; Brandao, Marcus L. [2] ; de Oliveira, Amanda R. [2, 1]
Total Authors: 5
[1] Fed Univ Sao Carlos UFSCar, Dept Psychol, Sao Carlos, SP - Brazil
[2] Inst Neurosci & Behav INeC, Ribeirao Preto, SP - Brazil
[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 - USA
Total Affiliations: 3
Document type: Journal article
Source: Experimental Brain Research; v. 239, n. 6, p. 1963-1974, JUN 2021.
Web of Science Citations: 0

Dopamine seems to mediate fear conditioning through its action on D2 receptors in the mesolimbic pathway. Systemic and local injections of dopaminergic agents showed that D2 receptors are preferentially involved in the expression, rather than in the acquisition, of conditioned fear. To further examine this issue, we evaluated the effects of systemic administration of the dopamine D2-like receptor antagonists sulpiride and haloperidol on the expression and extinction of contextual and cued conditioned fear in rats. Rats were trained to a context-CS or a light-CS using footshocks as unconditioned stimuli. After 24 h, rats received injections of sulpiride or haloperidol and were exposed to the context-CS or light-CS for evaluation of freezing expression (test session). After another 24 h, rats were re-exposed to the context-CS or light-CS, to evaluate the extinction recall (retest session). Motor performance was assessed with the open-field and catalepsy tests. Sulpiride, but not haloperidol, significantly reduced the expression of contextual and cued conditioned fear without affecting extinction recall. In contrast, haloperidol, but not sulpiride, had cataleptic and motor-impairing effects. The results reinforce the importance of D2 receptors in fear conditioning and suggest that dopaminergic mechanisms mediated by D2 receptors are mainly involved in the expression rather than in the extinction of conditioned freezing. (AU)

FAPESP's process: 16/04620-1 - Dopamine and neurokinins in the mediation of the sensorimotor gating of fear and anxiety
Grantee:Marcus Lira Brandão
Support type: Regular Research Grants