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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

STAT3 but Not ERK2 Is a Crucial Mediator Against Diet-Induced Obesity via VMH Neurons

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Goncalves, Gabriel Henrique Marques [1, 2] ; Tristao, Sabrina Mara [1] ; Volpi, Rafaella Eduarda [1] ; Almeida-Pereira, Gislaine [1] ; de Carvalho Borges, Beatriz [1] ; Donato, Jr., Jose [3] ; de Castro, Margaret [2] ; Antunes-Rodrigues, Jose [1] ; Elias, Lucila Leico Kagohara [1]
Total Authors: 9
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Physiol, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Div Endocrinol & Metab, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Diabetes; v. 70, n. 7, p. 1498-1507, JUL 2021.
Web of Science Citations: 0

Leptin plays an important role in the protection against diet-induced obesity (DIO) by its actions in ventromedial hypothalamic (VMH) neurons. However, little is known about the intracellular mechanisms involved in these effects. To assess the role of the STAT3 and ERK2 signaling in neurons that express the steroidogenic factor 1 (SF1) in the VMH in energy homeostasis, we used cre-lox technology to generate male and female mice with specific disruption of STAT3 or ERK2 in SF1 neurons of the VMH. We demonstrated that the conditional knockout of STAT3 in SF1 neurons of the VMH did not affect body weight, food intake, energy expenditure, or glucose homeostasis in animals on regular chow. However, with high-fat diet (HFD) challenge, loss of STAT3 in SF1 neurons caused a significant increase in body weight, food intake, and energy efficiency that was more remarkable in females, which also showed a decrease in energy expenditure. In contrast, deletion of ERK2 in SF1 neurons of VMH did not have any impact on energy homeostasis in both regular diet and HFD conditions. In conclusion, STAT3 but not ERK2 signaling in SF1 neurons of VMH plays a crucial role in protection against DIO in a sex-specific pattern. (AU)

FAPESP's process: 14/17248-8 - Role of STAT3 and ERK in SF1 neurons of hypothalamus in the effects of leptin and estradiol on energy homeostasis
Grantee:Lucila Leico Kagohara Elias
Support Opportunities: Regular Research Grants
FAPESP's process: 18/10090-0 - Role of STAT3 and PI3K signaling in SF1 neurons of the hypothalamus on energy homeostasis
Grantee:Gabriel Henrique Marques Gonçalves
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/09799-1 - Energy balance and body fluid homeostasis control: from cells to the physiological systems
Grantee:José Antunes Rodrigues
Support Opportunities: Research Projects - Thematic Grants