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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy assessed using the Morris Water Maze test

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Author(s):
Nejm, Mariana Bocca [1] ; Victorino, Daniella Balduino [1] ; Guimaraes-Marques, Marcia Jonathas [1] ; Scorza, Carla Alessandra [1] ; Finsterer, Josef [2] ; Scorza, Fulvio Alexandre [1] ; Cysneiros, Roberta Monterazzo [3]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Escola Paulista Med, Disciplina Neurociencia, Sao Paulo, SP - Brazil
[2] Vet Univ Vienna, Messerli Inst, Krankenanstalt Rudolfstiftung, Vienna - Austria
[3] Univ Presbiteriana Mackenzie, Lab Neurobiol & Metabolismo, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EPILEPTIC DISORDERS; v. 23, n. 3, p. 476-484, JUN 2021.
Web of Science Citations: 0
Abstract

Objective. Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy. Methods. We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test. Results. Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials. Significance. Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE. (AU)

FAPESP's process: 16/17746-3 - Evaluation of the effects of benzodiazepines on the in vivo electrophysiological activity of the brain and in vitro neuronal viability in the Ts65Dn mouse model
Grantee:Daniella Balduino Victorino
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/18568-7 - Sleep deprivation and possible heart changes in a model of Parkinson Disease induced by 6-Hydroxidopamine in rats: understanding for Sudden Death in Parkinson's Disease (SUDPAR).
Grantee:Fulvio Alexandre Scorza
Support type: Regular Research Grants
FAPESP's process: 16/06879-2 - Brain dynamics after stroke in a rodent from the Amazon rainforest
Grantee:Carla Alessandra Scorza Bahi
Support type: Regular Research Grants