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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

First complete genome sequence and molecular characterization of Canine morbillivirus isolated in Central Brazil

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da Costa, Vivaldo Gomes [1] ; Saivish, Marielena Vogel [2] ; de Oliveira, Priscila Gomes [3] ; Silva-Junior, Abelardo [4] ; Moreli, Marcos Lazaro [5] ; Kruger, Ricardo Henrique [1]
Total Authors: 6
[1] Univ Brasilia, Dept Cell Biol, Enzymol Lab, Brasilia, DF - Brazil
[2] Fac Med Sao Jose do Rio Preto, Dept Dermatol Infect & Parasit Dis, Sao Paulo - Brazil
[3] Univ Fed Jatai, Inst Agr Sci, Vet Lab, Jatai, Go - Brazil
[4] Univ Fed Vicosa, Dept Vet, Lab Immunobiol & Anim Virol, Vicosa, MG - Brazil
[5] Univ Fed Jatai, Inst Hlth Sci, Virol Lab, Jatai, Go - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 11, n. 1 JUN 22 2021.
Web of Science Citations: 0

The Brazilian regions are still highly endemic areas for Canine morbillivirus {[}canine distemper virus (CDV)]. However, little is known regarding the genetic variability of the strain circulating in several Brazilian regions. Here, we report the first full-length genome and molecular characterization of CDV isolated from domestic dogs in the Brazilian Center-West region. Sequence alignment and phylogenetic analyses based on deduced amino acid and nucleotide sequences showed that the isolated strain is characterized as the South America-I/Europe genotype. However, it segregates into a CDV subgenotype branch. Interestingly, both H and F proteins have a gain of a potential N-glycosylation sites compared to the Onderstepoort vaccine strain. Therefore, this study provides a reference to further understand the epidemic and molecular characteristics of the CDV in Brazil. (AU)

FAPESP's process: 20/12875-5 - Development of the diagnostic method for Rocio virus and use of new compounds as inhibitors of flavivirus protease-helicase NS2B-NS3
Grantee:Marielena Vogel Saivish
Support type: Scholarships in Brazil - Doctorate