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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Regulatory T cells and vaccine effectiveness in older adults. Challenges and prospects

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Author(s):
Batista-Duharte, Alexander [1] ; Pera, Alejandra [2, 3] ; Alino, Salvador F. [4] ; Solana, Rafael [2, 3, 5]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Rod Araraquara Jau Km 1, BR-14800903 Araraquara, SP - Brazil
[2] Maimonides Inst Biomed Res Cordoba IMIBIC, Immunol & Allergy Grp, Cordoba - Spain
[3] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba - Spain
[4] Univ Valencia, Fac Med, Dept Pharmacol, Valencia - Spain
[5] Reina Sofia Univ Hosp, Immunol & Allergy Serv, Cordoba - Spain
Total Affiliations: 5
Document type: Review article
Source: International Immunopharmacology; v. 96, JUL 2021.
Web of Science Citations: 0
Abstract

Since the discovery of lymphocytes with immunosuppressive activity, increasing interest has arisen in their possible influence on the immune response induced by vaccines. Regulatory T cells (Tregs) are essential for maintaining peripheral tolerance, preventing autoimmune diseases, and limiting chronic inflammatory diseases. However, they also limit beneficial immune responses by suppressing anti-infectious and anti-tumor immunity. Mounting evidence suggests that Tregs are involved, at least in part, in the low effectiveness of immunization against various diseases where it has been difficult to obtain protective vaccines. Interestingly, increased activity of Tregs is associated with aging, suggesting a key role for these cells in the lower vaccine effectiveness observed in older people. In this review, we analyze the impact of Tregs on vaccination, with a focus on older adults. Finally, we address an overview of current strategies for Tregs modulation with potential application to improve the effectiveness of future vaccines targeting older populations. (AU)

FAPESP's process: 18/15187-2 - Effect of Foxp3 silencing on immunogenicity of vaccines against Sporothrix schenckii
Grantee:Alexander Batista Duharte
Support type: Scholarships abroad - Research Internship - Post-doctor