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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymeric biomaterials maintained the esthetic efficacy and reduced the cytotoxicity of in-office dental bleaching

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Ortecho-Zuta, Uxua [1] ; de Oliveira Duque, Carla Caroline [1] ; de Oliveira Ribeiro, Rafael Antonio [1] ; Leite, Maria Luisa [1] ; Soares, Diana Gabriela [2] ; Hebling, Josimeri [3] ; Fraga Briso, Andre Luiz [4] ; Souza Costa, Carlos Alberto [5]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara, SP - Brazil
[2] Sao Paulo Univ USP, Sch Dent, Dept Dent Endodont & Dent Mat, Bauru, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Dent, Dept Morphol & Pediat Dent, Araraquara, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Dent, Dept Restorat Dent, Aracatuba - Brazil
[5] Sao Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, Humaita St 1680, BR-14801385 Araraquara, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Esthetic and Restorative Dentistry; v. 33, n. 8 JUL 2021.
Web of Science Citations: 0

Evaluate the kinetics of hydrogen peroxide (H2O2) degradation, esthetic efficacy and cytotoxicity of a bleaching gel with 35%H2O2 applied on enamel previously covered or not with polymeric nanofibrillar scaffold (SNan), polymeric primer catalyst (PPol), and both. Standardized enamel/dentin discs (n = 128) obtained from bovine teeth were adapted to pulp chambers. After covering enamel with the polymeric products, the bleaching gel was applied for 45 min, establishing the following groups: G1: no treatment (negative control); G2: 35%H2O2 (positive control); G3: SNan; G4: PPol; G5: SNan + PPol; G6: SNan + 35%H2O2; G7: PPol + 35%H2O2; G8: SNan + PPol + 35%H2O2. The kinetics of H2O2 degradation (n = 8), bleaching efficacy (Delta E/Delta WI; n = 8), trans-amelodentinal cytotoxicity (n = 8), and cell morphology (n = 4) were assessed (ANOVA/Tukey test; p < 0.05). Greater H2O2 degradation occurred in G7 and G8. Bleaching efficacy (Delta E) was higher in G6, G7, and G8 in comparison with G2 (p < 0.05). However, no difference was observed for Delta WI (p > 0.05). G8 presented the lower level of trans-amelodentinal diffusion of H2O2, oxidative stress, and toxicity to the MDPC-23 cells (p < 0.05). Polymeric biomaterials increased the kinetics of H2O2 decomposition, as well as maintained the esthetic efficacy and minimized the cytotoxicity caused by a bleaching gel with 35%H2O2. Clinical Significance Application of a bleaching gel with 35%H2O2 on enamel previously covered by polymeric biomaterials maintains the esthetic efficacy and reduces the cytotoxicity caused by a single session of in-office dental bleaching. (AU)

FAPESP's process: 17/22739-9 - Development and analysis of a bilayer scaffold for pulp-dentin regeneration
Grantee:Carlos Alberto de Souza Costa
Support Opportunities: Regular Research Grants