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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ventricular Fibrosis and Coronary Remodeling Following Short-Term Exposure of Healthy and Malnourished Mice to Bisphenol A

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Garcia-Arevalo, Marta [1, 2] ; Lorza-Gil, Estela [1, 2] ; Cardoso, Leandro [2] ; Batista, Thiago Martins [1, 2] ; Araujo, Thiago Reis [1, 2] ; Ferreira Ramos, Luiz Alberto [2] ; Areas, Miguel Arcanjo [2] ; Nadal, Angel [3] ; Carneiro, Everardo Magalhaes [1, 2] ; Davel, Ana Paula [2]
Total Authors: 10
[1] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas - Brazil
[2] Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil
[3] Univ Miguel Hernandez, Spanish Biomed Res Ctr Diabet & Associated Metab, Inst Biol Mol & Celular, Inst Invest Desarrollo Innovac Biotecnol Sanitari, Elche - Spain
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN PHYSIOLOGY; v. 12, APR 12 2021.
Web of Science Citations: 0

Bisphenol-A (BPA) is an endocrine disruptor associated with higher risk of insulin resistance, type 2 diabetes, and cardiovascular diseases especially in susceptible populations. Because malnutrition is a nutritional disorder associated with high cardiovascular risk, we sought to compare the effects of short-term BPA exposure on cardiovascular parameters of healthy and protein-malnourished mice. Postweaned male mice were fed a normo- (control) or low-protein (LP) diet for 8 weeks and then exposed or not to BPA (50 mu g kg(-1) day(-1)) for the last 9 days. Systolic blood pressure was higher in BPA or LP groups compared with the control group. However, diastolic blood pressure was enhanced by BPA only in malnourished mice. Left ventricle (LV) end diastolic pressure (EDP), collagen deposition, and CTGF mRNA expression were higher in the control or malnourished mice exposed to BPA than in the respective nonexposed groups. Nevertheless, mice fed LP diet exposed to BPA exhibited higher angiotensinogen and cardiac TGF-beta 1 mRNA expression than mice treated with LP or BPA alone. Wall:lumen ratio and cross-sectional area of intramyocardial arteries were higher either in the LP or BPA group compared with the control mice. Taken together, our data suggest that short-term BPA exposure results in LV diastolic dysfunction and fibrosis, and intramyocardial arteries inward remodeling, besides potentiate protein malnutrition-induced hypertension and cardiovascular risk. (AU)

FAPESP's process: 18/26080-4 - Characterization of molecular and functional mechanisms involved in endocrine-metabolic, cardiovascular and neural dysfunctions induced by the restriction of amino acids in vitro and in vivo: possible therapeutic role of bile acid TUDCA
Grantee:Everardo Magalhães Carneiro
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/09532-8 - Functional and molecular analysis of estrogen receptors in the islets of Langerhans and peripheral tissues of malnourished mice and their involvement in glycemic control
Grantee:Marta García-Arévalo Provencio
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/01717-9 - Investigation of the insulinotropic, insulinomimetic and endothelial actions of taurine in cells/tissues submitted to an in vitro amino acid restriction: an integrated and multifocal approach
Grantee:Everardo Magalhães Carneiro
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC