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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Physical and functional well-being and symptoms of ovarian cancer in women undergoing first-line of chemotherapy: a one-year follow-up

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Author(s):
Ferracini, Amanda Canato [1] ; Pereira, Gabriela [2] ; de Souza, Cinthia Madeira [3] ; dos Santos, Thiago Fortes Cabello [4] ; Sarian, Luis Otavio [5] ; Derchain, Sophie [5] ; Mazzola, Priscila Gava [6]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Grad Program Med Sci, Fac Med Sci, Sch Med Sci, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Grad Program Pharmaceut Sci, 200 Candido Portinari, BR-13083871 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Grad Program Gerontol, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[4] Pontifical Catholic Univ Campinas, Ctr Life Sci, Fac Med, BR-13034685 Campinas, SP - Brazil
[5] Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynecol, 126 Tessalia Vieira de Camargo, BR-13083887 Campinas, SP - Brazil
[6] Univ Estadual Campinas, Fac Pharmaceut Sci, 200 Candido Portinari, BR-13083871 Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SUPPORTIVE CARE IN CANCER; JUN 2021.
Web of Science Citations: 0
Abstract

Purpose Clinicopathological features and chemotherapy can influence the quality of life (QOL), women with ovarian cancer. This study aimed to evaluate the physical and functional well-being, and ovarian cancer-specific effects scores reported from QOL questionnaire among women with ovarian cancer at the time of in their initial diagnosis and access the scores trajectory of women receiving neoadjuvant and adjuvant chemotherapy. Methods This prospective study used cross-sectional analysis at baseline and longitudinal analysis from baseline to 12-month post-chemotherapy. QOL was evaluated at the baseline, at sixth cycle and 12-month post-chemotherapy using FACT-O questionnaire. Clinicopathological features and chemotherapy regime were evaluated and tested for associations with QOL measures. Results Of the 38 women enrolled in this study, 27 (80.1%) completed the questionnaire for 12 months. The multivariate linear regression results suggest, at the baseline, women with advance stage and presence of post-surgery residual disease showed lower scores in physical and functional well-being, ovarian cancer-specific effects, and FACT-O TOI domains (p < 0.05). Longitudinal analysis spanning over 12 months showed an improvement in mean physical well-being, functional well-being, and ovarian cancer-specific effects scores, independent of chemotherapy received (p < 0.05). Conclusions At the baseline, the clinicopathological features such as stage, presence of post-surgery residual disease, and type of chemotherapy correlated with on QOL scores. At one-year follow-up, women who underwent chemotherapy showed improvement in QOL regardless of the type of chemotherapy they received. Future prospective study with a larger group is recommended. (AU)

FAPESP's process: 19/24093-4 - Markers related to tumor microenvironment in women with ovarian carcinoma
Grantee:Thiago Fortes Cabello dos Santos
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/22335-2 - Evaluation of genetic markers and quality of life in women with ovarian carcinoma
Grantee:Amanda Canato Ferracini
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/00070-2 - Understanding EPHA5 signaling in the effects of paclitaxel-induced peripheral neuropathy on human-induced pluripotent stem cell derived sensory neurons
Grantee:Amanda Canato Ferracini
Support Opportunities: Scholarships abroad - Research Internship - Doctorate