Noriega-Prieto, Jose Antonio
Maglio, Laura Eva
[2, 3, 4]
Zegarra-Valdivia, Jonathan A.
[5, 6, 7]
Fernandez, Ana M.
de Sevilla, David Fernandez
Total Authors: 11
 Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 - USA
 Univ Autonoma Madrid, Fac Med, Dept Anat Histol & Neurociencia, Madrid 28029 - Spain
 Univ La Laguna, Dept Ciencias Med Basicas Fisiol, Tenerife 38071 - Spain
 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28031 - Spain
 Univ Nacl San Agustin Arequipa, Arequipa 04001 - Peru
 Univ Fed Sao Paulo, BR-04021001 Sao Paulo - Brazil
Total Affiliations: 8
JOURNAL OF NEUROSCIENCE;
JUN 2 2021.
Web of Science Citations:
Insulin-like growth factor-I (IGF-I) signaling plays a key role in learning and memory processes. While the effects of IGF-I on neurons have been studied extensively, the involvement of astrocytes in IGF-I signaling and the consequences on synaptic plasticity and animal behavior remain unknown. We have found that IGF-I induces long-term potentiation (LTPIGFI) of the postsynaptic potentials that is caused by a long-term depression of inhibitory synaptic transmission in mice. We have demon-strated that this long-lasting decrease in the inhibitory synaptic transmission is evoked by astrocytic activation through its IGF-I receptors (IGF-IRs). We show that LTPIGFI not only increases the output of pyramidal neurons, but also favors the NMDAR-dependent LTP, resulting in the crucial information processing at the barrel cortex since specific deletion of IGF-IR in cortical astrocytes impairs the whisker discrimination task. Our work reveals a novel mechanism and functional conse-quences of IGF-I signaling on cortical inhibitory synaptic plasticity and animal behavior, revealing that astrocytes are key ele-ments in these processes. (AU)