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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Astrocytic IGF-IRs Induce Adenosine-Mediated Inhibitory Downregulation and Improve Sensory Discrimination

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Author(s):
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Noriega-Prieto, Jose Antonio [1, 2] ; Maglio, Laura Eva [2, 3, 4] ; Zegarra-Valdivia, Jonathan A. [5, 6, 7] ; Pignatelli, Jaime [5, 6] ; Fernandez, Ana M. [5, 6] ; Martinez-Rachadell, Laura [5, 6] ; Fernandes, Jansen [5, 8] ; Nunez, Angel [2] ; Araque, Alfonso [1] ; Torres-Aleman, Ignacio [5, 6] ; de Sevilla, David Fernandez [2]
Total Authors: 11
Affiliation:
[1] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 - USA
[2] Univ Autonoma Madrid, Fac Med, Dept Anat Histol & Neurociencia, Madrid 28029 - Spain
[3] Univ La Laguna, Dept Ciencias Med Basicas Fisiol, Tenerife 38071 - Spain
[4] Univ La Laguna, Inst Tecnol Biomed, Tenerife 38071 - Spain
[5] CSIC, Inst Cajal, Madrid 28002 - Spain
[6] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid 28031 - Spain
[7] Univ Nacl San Agustin Arequipa, Arequipa 04001 - Peru
[8] Univ Fed Sao Paulo, BR-04021001 Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: JOURNAL OF NEUROSCIENCE; v. 41, n. 22, p. 4768-4781, JUN 2 2021.
Web of Science Citations: 0
Abstract

Insulin-like growth factor-I (IGF-I) signaling plays a key role in learning and memory processes. While the effects of IGF-I on neurons have been studied extensively, the involvement of astrocytes in IGF-I signaling and the consequences on synaptic plasticity and animal behavior remain unknown. We have found that IGF-I induces long-term potentiation (LTPIGFI) of the postsynaptic potentials that is caused by a long-term depression of inhibitory synaptic transmission in mice. We have demon-strated that this long-lasting decrease in the inhibitory synaptic transmission is evoked by astrocytic activation through its IGF-I receptors (IGF-IRs). We show that LTPIGFI not only increases the output of pyramidal neurons, but also favors the NMDAR-dependent LTP, resulting in the crucial information processing at the barrel cortex since specific deletion of IGF-IR in cortical astrocytes impairs the whisker discrimination task. Our work reveals a novel mechanism and functional conse-quences of IGF-I signaling on cortical inhibitory synaptic plasticity and animal behavior, revealing that astrocytes are key ele-ments in these processes. (AU)

FAPESP's process: 17/14742-0 - Effects of prenatal exercise on behavioral, morphological and epigenetic changes in the offspring of immune-challenged mothers
Grantee:Jansen Fernandes
Support type: Scholarships in Brazil - Post-Doctorate