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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of P2X7 Receptors in Immune Responses During Neurodegeneration

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Oliveira-Giacomelli, Agatha [1] ; Petiz, Lyvia Lintzmaier [1] ; Andrejew, Roberta [1] ; Turrini, Natalia [1] ; Silva, Jean Bezerra [1] ; Sack, Ulrich [2] ; Ulrich, Henning [1, 2]
Total Authors: 7
[1] Univ Sao Paulo, Dept Biochem, Inst Chem, Sao Paulo - Brazil
[2] Univ Leipzig, Med Fac, Inst Clin Immunol, Leipzig - Germany
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 0

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine release. These inflammatory conditions, whether occurring peripherally or in the central nervous system (CNS), increase blood-brain-barrier (BBB) permeability. Besides its well-known involvement in neurodegeneration and neuroinflammation, the P2X7 receptor may induce BBB disruption and chemotaxis of peripheral immune cells to the CNS, resulting in brain parenchyma infiltration. For instance, despite common effects on cytokine release, P2X7 receptor signaling is also associated with metalloproteinase secretion and activation, as well as migration and differentiation of T lymphocytes, monocytes and dendritic cells. Here we highlight that peripheral immune cells mediate the pathogenesis of Multiple Sclerosis and Parkinson's and Alzheimer's disease, mainly through T lymphocyte, neutrophil and monocyte infiltration. We propose that P2X7 receptor activation contributes to neurodegenerative disease progression beyond its known effects on the CNS. This review discusses how P2X7 receptor activation mediates responses of peripheral immune cells within the inflamed CNS, as occurring in the aforementioned diseases. (AU)

FAPESP's process: 18/08426-0 - Indole alkaloid sub products of Maqui (Aristotelia chilensis) processing as food additives to Alzheimer's Disease treatment
Grantee:Alexander Henning Ulrich
Support type: Regular Research Grants
FAPESP's process: 19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease
Grantee:Roberta Andrejew Caetano
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases
Grantee:Alexander Henning Ulrich
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease
Grantee:Ágatha Oliveira Giacomelli
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 20/10725-6 - Evaluation of purinergic receptors in the comorbidity of bipolar disorder and Alzheimer's Disease
Grantee:Natalia Turrini
Support type: Scholarships in Brazil - Doctorate (Direct)