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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of 5-HT1A receptors in the ventral hippocampus in the regulation of anxiety- and panic-related defensive behaviors in rats

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Hernandes, Paloma Molina [1] ; Batistela, Matheus Fitipaldi [1] ; Vilela-Costa, Heloisa Helena [1] ; Sant `Ana, Ana Beatriz ; Kumpel, Vinicius Dias [2] ; Tirapelle, Mariane Cariati [2] ; Bom, Ariela de Oliveira Pedro [2] ; de Andrade, Telma Goncalves Carneiro Spera [2] ; Zangrossi Jr, Helio
Total Authors: 9
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Biol Sci, Assis, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Behavioural Brain Research; v. 408, JUN 25 2021.
Web of Science Citations: 0

Changes in 5-HT1A receptor (5-HT1AR)-mediated neurotransmission in the hippocampus have been associated with anxiety, depression and in the mode of action of antidepressant drugs. It has been commonly accepted that whereas the dorsal pole of the hippocampus (DH) is involved in cognitive processing, the ventral pole (VH) is associated with emotional regulation. However, to date, only a few studies have directly addressed the role played by VH 5-HT1ARs in anxiety and panic processing, and their results are conflicting. Here we report that intra-VH administration of the 5-HT1A receptor agonist 8-OH-DPAT, the endogenous agonist serotonin (5-HT), or the standard anxiolytic benzodiazepine midazolam impaired the acquisition of inhibitory avoidance in the elevated T-maze (ETM) of male Wistar rats, indicating an anxiolytic effect. Conversely, local injection of the 5HT1AR antagonist WAY-100635 caused the opposite effect. These results were equally found in the Vogel conflict test. None of these drugs interfered with locomotor activity in the open-field test, nor did they alter the expression of the escape response in the ETM, a defensive behavior associated with panic. Pre-injection of a subeffective dose of WAY-100635 in the VH blocked the anxiolytic effect of 5-HT or 8-OH-DPAT in the Vogel test, confirming the involvement of 5-HT1AR for this behavioral effect. The effect in this test was anxiety-selective as none of the drugs affected water consumption or nociception. In conclusion, our results suggest that 5-HT1ARs in the VH play a tonic inhibitory role in anxiety processing. These receptors, however, are not involved in the regulation of panic-related escape behavior. (AU)

FAPESP's process: 16/16015-5 - Serotonergic activity in ventral hippocampus on 5th2a receptors in the regulation of the defensive behaviours related to generalized anxiety and panic
Grantee:Paloma Molina Hernandes
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/18437-7 - Investigation of the role of 5-HT1A receptors located in the lateral wings of the dorsal raphe nucleus on the panicolytic effect promoted by fluoxetine treatment
Grantee:Heloísa Helena Vilela Costa
Support Opportunities: Scholarships in Brazil - Post-Doctoral