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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of residual antimicrobial activity and acute toxicity during the degradation of gatifloxacin by ozonation

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Author(s):
Caianelo, Marlon [1] ; Rodrigues-Silva, Caio [2] ; Maniero, Milena Guedes [1] ; Diniz, Vinicius [2] ; Spina, Mylena [1] ; Guimaraes, Jose Roberto [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Sch Civil Engn Architecture & Urban Design, POB 6143, BR-13083889 Campinas - Brazil
[2] Univ Estadual Campinas, Dept Analyt Chem, Inst Chem, POB 6154, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: WATER SCIENCE AND TECHNOLOGY; v. 84, n. 1 MAY 2021.
Web of Science Citations: 0
Abstract

The concerns regarding the occurrence of pharmaceuticals in wastewater treatment plants have been increased in the last decades. Gatifloxacin (GAT), the fourth generation of fluoroquinolones, has been widely used to treat both Gram-positive and Gram-negative bacteria and has a limited metabolization. The present study aimed to evaluate the ozonation as a technique to degrade GAT. A UHPLC-MS/MS method was used to quantify the residual of GAT and to assess its degradation products. The removal efficiency was higher at alkaline condition (pH = 10), reaching up to 99% of GAT after 4 min. It was also observed that the first ozone attack on the GAT molecule was through the carboxylic group. In contrast, at acid conditions (pH = 3), the ozone attack was first to the piperazinyl ring. The antimicrobial activity was evaluated using Escherichia coli and Bacillus subtilis as test organisms, and it was observed that the residual activity reduced most at the alkaline conditions. In contrast, the best condition to remove the residual toxicity evaluated for the marine bacteria V. fischeri was the acidic one. Due to this, the ozonation seemed to be an exciting process to remove GAT at aqueous media. (AU)

FAPESP's process: 13/09543-7 - Residues of veterinary drugs in the environment
Grantee:Susanne Rath
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/16622-3 - Identification of intermediates formed during degradation of veterinary drugs by advanced oxidation processes
Grantee:Caio Alexandre Augusto Rodrigues da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/03571-2 - Pharmaceuticals in the Aquatic Environment.
Grantee:Susanne Rath
Support type: Regular Research Grants
FAPESP's process: 14/50951-4 - INCT 2014: Advanced Analytical Technologies
Grantee:Celio Pasquini
Support type: Research Projects - Thematic Grants