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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epidemiology and evolution of Zika virus in Minas Gerais, Southeast Brazil

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Iani, Felipe C. M. [1, 2, 3] ; Giovanetti, Marta [2, 4] ; Fonseca, Vagner [2, 5, 6] ; Souza, William M. [1, 7] ; Adelino, Talita E. R. [2, 3] ; Xavier, Joilson [2] ; Jesus, Jaqueline G. [8, 7] ; Pereira, Maira A. [3] ; Silva, Marcos V. F. [9, 3] ; Costa, Alana V. B. [9, 3] ; Silva, Erniria C. ; Mendes, Marcia C. O. ; Filippis, Ana M. B. [4] ; Albuquerque, Carlos F. C. [10] ; Abreu, Andre L. [6] ; Oliveira, Marluce A. A. [3] ; Alcantara, Luiz C. J. [2] ; Faria, Nuno R. [1, 8, 11]
Total Authors: 18
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[1] Univ Oxford, Dept Zool, Oxford - England
[2] Univ Fed Minas Gerais, Lab Genet Celular & Mol, Belo Horizonte, MG - Brazil
[3] Fundacao Ezequiel Dias, Lab Cent Saude Publ, Belo Horizonte, MG - Brazil
[4] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Flavivirus, Rio De Janeiro - Brazil
[5] Univ KwaZulu Natal, Coll Hlth Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, ZA-4001 Durban - South Africa
[6] Minist Saude, Secretaria Vigilancia Saude, Lab Saude Publ, Brasilia, DF - Brazil
[7] Univ Sao Paulo, Fac Med Ribeirao Preto, Ctr Pesquisa Virol, Ribeirao Preto - Brazil
[8] Univ Sao Paulo, Fac Med, Inst Med Trop, Sao Paulo - Brazil
[9] Secretaria Estado Saude Minas Gerais, Belo Horizonte, MG - Brazil
[10] Org Mundial Saude, Org Pan Americana Saude, Brasilia, DF - Brazil
[11] Imperial Coll London, J IDEA, MRC Ctr Global Infect Dis Anal, London - England
Total Affiliations: 11
Document type: Journal article
Web of Science Citations: 2

Autochthonous Zika virus (ZIKV) transmission in Brazil was first identified in April 2015 in Brazil, with the first ZIKV-associated microcephaly cases detected in October 2015. Despite efforts on understanding ZIKV transmission in Brazil, little is known about the virus epidemiology and genetic diversity in Minas Gerais (MG), the second most populous state in the country. We report molecular and genomic findings from the main public health laboratory in MG. Until January 2020, 26,817 ZIKV suspected infections and 86 congenital syndrome cases were reported in MG state. We tested 8552 ZIKV and microcephaly suspected cases. Ten genomes were generated on-site directly from clinical samples. A total of 1723 confirmed cases were detected in Minas Gerais, with two main epidemic waves; the first and larger epidemic wave peaked in March 2016, with the second smaller wave that peaked in March 2017. Dated molecular clock analysis revealed that multiple introductions occurred in Minas Gerais between 2014 and 2015, suggesting that the virus was circulating unnoticed for at least 16 months before the first confirmed laboratory case that we retrospectively identified in December 2015. Our findings highlight the importance of continued genomic surveillance strategies combined with traditional epidemiology to assist public health laboratories in monitoring and understanding the diversity of circulating arboviruses, which might help attenuate the public health impact of infectious diseases. (AU)

FAPESP's process: 19/12000-1 - Modeling of the spatiotemporal dispersion of emergent arboviruses using heterogeneous data sources in the State of São Paulo
Grantee:Jaqueline Goes de Jesus
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
Grantee:Ester Cerdeira Sabino
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease
Grantee:William Marciel de Souza
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 18/17176-8 - Real-time, rapid detection and sequencing of arboviruses in Brazil: Zika, Dengue, Chikungunya and Yellow Fever
Grantee:Ingra Morales Claro
Support type: Scholarships in Brazil - Doctorate (Direct)