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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Regular swimming exercise prevented the acute and persistent mechanical muscle hyperalgesia by modulation of macrophages phenotypes and inflammatory cytokines via PPAR gamma receptors

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de Azambuja, Graciana [1] ; Jorge, Carolina O. [1] ; Gomes, Beatriz B. [1] ; Lourenco, Hayla R. [1] ; Simabuco, Fernando M. [2] ; Oliveira-Fusaro, Maria Claudia G. [1]
Total Authors: 6
[1] Univ Estadual Campinas, Sch Appl Sci, Lab Pain & Inflammat Res, Campinas - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Multidisciplinary Lab Food & Hlth, Campinas - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BRAIN BEHAVIOR AND IMMUNITY; v. 95, p. 462-476, JUL 2021.
Web of Science Citations: 0

Physically active individuals are less likely to develop chronic pain, and physical exercise is an established strategy to control inflammatory diseases. Here, we hypothesized that 1) peripheral pro-inflammatory macrophages phenotype contribute to predisposition of the musculoskeletal to chronic pain, and that 2) activation of PPAR gamma receptors, modulation of macrophage phenotypes and cytokines through physical exercise would prevent persistent muscle pain. We tested these hypotheses using swimming exercise, pharmacological and immunochemical techniques in a rodent model of persistent muscle hyperalgesia. Swimming prevented the persistent mechanical muscle hyperalgesia most likely through activation of PPAR gamma receptors, as well as activation of PPAR gamma receptors by 15d-PGJ2 and depletion of muscle macrophages in sedentary animals. Acute and persistent muscle hyperalgesia were characterized by an increase in pro-inflammatory macrophages phenotype, and swimming and the 15d-PGJ2 prevented this increase and increased anti-inflammatory macrophages phenotype. Finally, IL-1 beta concentration in muscle increased in the acute phase, which was also prevented by PPAR gamma receptors activation through swimming. Besides, swimming increased muscle concentration of IL-10 in both acute and chronic phases, but only in the persistent phase through PPAR gamma receptors. Our findings suggest physical exercise activates PPAR gamma receptors and increases anti-inflammatory responses in the muscle tissue by modulating macrophages phenotypes and cytokines, thereby preventing the establishment of persistent muscle hyperalgesia. These results further highlight the potential of physical exercise to prevent chronic muscle pain. (AU)

FAPESP's process: 18/13599-1 - Inflammatory mechanisms underlying muscle pain chronification and its prevention by physical exercise: study of macrophages, PPAR gamma and P2X4 receptors involvment
Grantee:Graciana de Azambuja
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/17919-8 - Exercise-induced prevention of chronicity of muscle pain: involvement of neuroimmune mechanisms
Grantee:Maria Cláudia Gonçalves de Oliveira
Support Opportunities: Regular Research Grants