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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

pilot study indicating the dysregulation of the complement and coagulation cascades in treated schizophrenia and bipolar disorder patient

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Santa Cruz, Elisa Castaneda [1] ; Zandonadi, Flavia da Silva [1] ; Fontes, Wagner [2] ; Sussulini, Alessandra [1, 3]
Total Authors: 4
[1] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOmics, BR-13083970 Campinas, SP - Brazil
[2] Univ Brasilia UnB, Inst Biol, Dept Cell Biol, Lab Prot Chem & Biochem, BR-70910900 Brasilia, DF - Brazil
[3] Univ Campinas UNICAMP, Natl Inst Sci & Technol Bioanalyt INCTBio, Inst Chem, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 1

A better understanding of the proteome profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, besides monitoring disease progression, may assist on the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this pilot study, proteomics analysis employing nano liquid chromatography coupled to mass spectrometry (nLC-MS) and bioinformatic tools were applied to identify differentially abundant proteins in serum of treated BD and SCZ patients. In total, 10 BD patients, 10 SCZ patients, and 14 healthy controls (HC) were included in this study. 24 serum proteins were significantly altered (p < 0.05) in BD and SCZ treated patients and, considering log(2)FC > 0.58, 8 proteins presented lower abundance in the BD group, while 7 proteins presented higher abundance and 2 lower abundance in SCZ group when compared against HC. Bioinformatics analysis based on these 24 proteins indicated two main altered pathways previously described in the literature; furthermore, it revealed that opposite abundances of the complement and coagulation cascades were the most significant biological processes involved in these pathologies. Moreover, we describe disease-related proteins and pathways associations suggesting the necessity of clinical follow-up improvement besides treatment, as a precaution or safety measure, along with the disease progression. Further biological validation and investigations are required to define whether there is a correlation between complement and coagulation cascade expression for BD and SCZ and cardiovascular diseases. (AU)

FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Lauro Tatsuo Kubota
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/01525-3 - Metabolomic studies of depression patients treated with ayahuasca
Grantee:Alessandra Sussulini
Support type: Regular Research Grants