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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

nterleukin-6 ablation does not alter morphofunctional heart characteristics but modulates physiological and inflammatory markers after strenuous exercis

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da Rocha, Alisson L. [1] ; Rovina, Rafael L. [2] ; Pinto, Ana P. [1] ; Marafon, Bruno B. [2] ; da Silva, Lilian E. C. M. [3] ; Simabuco, Fernando M. [4] ; Frantz, Fabiani G. [5] ; Pauli, Jose R. [4] ; de Moura, Leandro P. [4] ; Cintra, Dennys E. [4] ; Ropelle, Eduardo R. [4] ; Filho, Hugo T. [2] ; de Freitas, Ellen C. [2] ; Rivas, Donato A. [6] ; da Silva, Adelino S. R. [2, 1]
Total Authors: 15
[1] Univ Sao Paulo, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
[4] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, UNICAMP, Limeira, SP - Brazil
[5] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP - Brazil
[6] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 - USA
Total Affiliations: 6
Document type: Journal article
Source: CYTOKINE; v. 142, JUN 2021.
Web of Science Citations: 0

Interleukin-6 (IL-6) is associated with pathological cardiac hypertrophy and can be dramatically increased in serum after an acute strenuous exercise session. However, IL-6 is also associated with the increased production and release of anti-inflammatory cytokines and the inhibition of tumor necrosis factor-alpha (TNF-?) after chronic moderate exercise. To elucidate the relevance of IL-6 in inflammatory and hypertrophic signaling in the heart in response to an acute strenuous exercise session, we combined transcriptome analysis using the BXD mice database and exercised IL-6 knockout mice (IL-6KO). Bioinformatic analysis demonstrated that low or high-levels of Il6 mRNA in the heart did not change the inflammation- and hypertrophy-related genes in BXD mice strains. On the other hand, bioinformatic analysis revealed a strong positive correlation between Il6 gene expression in skeletal muscle with inflammation-related genes in cardiac tissue in several BXD mouse strains, suggesting that skeletal muscle-derived IL-6 could alter the heart?s intracellular signals, particularly the inflammatory signaling. As expected, an acute strenuous exercise session increased IL-6 levels in wild-type, but not in IL-6KO mice. Despite not showing morphofunctional differences in the heart at rest, the IL-6KO group presented a reduction in physical performance and attenuated IL-6, TNF-?, and IL-1beta kinetics in serum, as well as lower p38MAPK phosphorylation, Ampkalpha expression, and higher Acta1 and Tnf gene expressions in the left ventricle in the basal condition. In response to strenuous exercise, IL-6 ablation was linked to a reduction in the proinflammatory response and higher activation of classical physiological cardiac hypertrophy proteins. (AU)

FAPESP's process: 19/17058-8 - Role of interleukin-6 in the responses of the autophagic pathway in the heart of mice submitted in acute exhaustive physical exercise
Grantee:Rafael Lemes Rovina
Support type: Scholarships in Brazil - Master
FAPESP's process: 17/17646-1 - Circulating microRNA as novel predictors of skeletal muscle anabolic response in aged humans
Grantee:Adelino Sanchez Ramos da Silva
Support type: Scholarships abroad - Research
Grantee:Adelino Sanchez Ramos da Silva
Support type: Regular Research Grants
FAPESP's process: 19/00855-2 - Sarcopenia, nutrition, and physical activity
Grantee:Adelino Sanchez Ramos da Silva
Support type: Research Grants - Visiting Researcher Grant - International