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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Identification of differentially expressed miRNAs in human cells infected with different Zika virus strains

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Machado, Francielly Cristina [1] ; Bittar, Cintia [1] ; Rahal, Paula [1] ; Calmon, Marilia Freitas [1]
Total Authors: 4
[1] Sao Paulo State Univ, UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, IBILCE, Rua Cristovao Colombo 2265, Bairro Jardim Nazareth, BR-15054010 Sao Jose De Rio Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ARCHIVES OF VIROLOGY; v. 166, n. 6 APR 2021.
Web of Science Citations: 0

Infection with distinct Zika virus (ZIKV) strains in in vitro and in vivo models has demonstrated that the host's response to infection is strain-dependent. There has been no analysis of the impact of infection with different ZIKV strains on miRNA expression in human cells. We investigated miRNA expression in PNT1A cells upon infection with an African ZIKV strain (MR766) and a Brazilian ZIKV strain (ZIKV(BR)) using PCR array. Sixteen miRNAs were modulated in PNT1A cells: six miRNAs were modulated by both strains, while a set of ten miRNAs were modulated exclusively by ZIKV(BR) infection. In silico analysis showed that nine significant KEGG pathways and eight significant GO terms were predicted to be enriched upon ZIKV(BR) infection, and these pathways were related to cancer, environmental information processing, metabolism, and extracellular matrix. Differential modulation of miRNA expression suggests that distinct strains of ZIKV can differentially modulate the host response through the action of miRNAs. (AU)

FAPESP's process: 17/09197-2 - Analysis of miRNA expression in human prostate cells infected with Zika virus
Grantee:Francielly Cristina Machado
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/22198-0 - Therapeutic potential of Flavonoid-like drugs on Hepatitis C virus infection
Grantee:Paula Rahal
Support Opportunities: Regular Research Grants
FAPESP's process: 15/16660-5 - Analysis of the nanoemulsions associated with photodynamic therapy in the treatment of breast cancer
Grantee:Marilia de Freitas Calmon
Support Opportunities: Regular Research Grants