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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

enetic variants of HPV-16 and their geographical and anatomical distribution in men: A systematic review with meta-analysi

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Ferreira, Matthew Thomas [1] ; Goncalves, Milena Giulia [1] ; Lopez, Rossana Veronica Mendoza [1] ; Sichero, Laura [1]
Total Authors: 4
[1] Univ Sao Paulo FMUSP HC, Inst Canc Estado Sao Paulo ICESP, Hosp Clin, Ctr Translat Res Oncol, Fac Med, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: VIROLOGY; v. 558, p. 134-144, JUN 2021.
Web of Science Citations: 0

Background: The prevalence of Human Papillomavirus type 16 (HPV-16) variants in men and the association with tumor development has not been fully investigated. We estimated the prevalence of genital, anal, and oral HPV16 infections in men through a systematic review and meta-analysis. Methods: Seven databases were searched and included studies that identified HPV-16 positive males, HPV-16 variants (lineages/sublineages), and indicated the sample?s anatomical origin. This protocol is registered in PROSPERO (CRD42020178013). Results: The database searches yielded 14 studies including 445 HPV-16 positive samples classified as lineage A (n = 390), lineage D (n = 43), lineage B (n = 10), and lineage C (n = 2) variants. Lineage A variants predominated among the anatomical sites and the diverse geographical regions. Conclusions: HPV-16 lineages vary according to anatomical and geographical region. According to this preliminary evaluation of the current literature, we hypothesize that, similar to women, specific HPV-16 variants may also be associated to increased cancer risk in men. (AU)

FAPESP's process: 19/15717-4 - Analysis of the prevalence and persistence of HPV-16 variant infection in the genital region of men.
Grantee:Matthew Thomas Ferreira
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/23211-8 - Impact of genetic variants of HPV on persistence of infection and risk of disease: an epidemiological and functional approach
Grantee:Laura Cristina Sichero Vettorazzo
Support Opportunities: Research Projects - Thematic Grants