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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metronidazole and amoxicillin for patients with periodontitis and diabetes mellitus: 5 years secondary analysis of a randomized controlled trial

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Cruz, Daniele Ferreira da [1] ; Duarte, Poliana Mendes [1, 2] ; de Figueiredo, Luciene Cristina [1] ; da Silva, Helio Doyle Pereira [1] ; Retamal-Valdes, Belen [1] ; Feres, Magda [1] ; Miranda, Tamires Szeremeske [1]
Total Authors: 7
[1] Univ Guarulhos, Dent Res Div, Dept Periodontol, Sao Paulo - Brazil
[2] Univ Florida, Coll Dent, Dept Periodontol, Gainesville, FL - USA
Total Affiliations: 2
Document type: Journal article
Source: Journal of Periodontology; v. 92, n. 4, p. 479-487, APR 2021.
Web of Science Citations: 0

Background The aim of this study was to perform a 5-year follow-up analysis of a previously-published randomized trial (RCT) evaluating the 2-years effects of metronidazole (MTZ) plus amoxicillin (AMX) as adjuncts to scaling and root planing (SRP) in the treatment of periodontitis in type 2 diabetic patients. Methods Volunteers who received periodontal treatment in the aforementioned RCT were selected for clinical and microbiological evaluation. Patients did not receive regular supportive periodontal therapy (SPT) from 2 to 5 years post-treatment. Results Of the patients enrolled in the RCT, 43% entered this study (n = 10/control and 15/test group). Most of clinical parameter values, including the number of sites with probing depth >= 5 mm (primary outcome variable), were reduced at 5 years post-therapy when compared with baseline in the antibiotic-treated group (P < 0.05), but presented higher values than those at 2 years (P < 0.05). The mean proportions of microbial complexes did not differ between MTZ+AMX+SRP and SRP-only groups at 5 years post-treatment (P > 0.05). Conclusion Diabetic patients treated with adjunctive MTZ+AMX were better maintained over a period of 5 years than those treated with SRP only. However, the clinical and microbiological benefits obtained up to 2 years post-treatment were not fully sustained in these patients who did not receive SPT between 2 and 5 years post-treatment. (AU)

FAPESP's process: 11/14872-4 - Systemic metronidazole and amoxicillin as adjuncts to scaling and root planing in the treatment of chronic periodontitis in type 2 diabetic subjects: clinical, glycemic and microbiological evaluations
Grantee:Tamires Szeremeske de Miranda
Support Opportunities: Scholarships in Brazil - Master