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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy

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Banin, Renata Mancini [1] ; Forcelini Machado, Meira Maria [2] ; de Andrade, Iracema Senna [1] ; Testa Carvalho, Lorenza Oliveira [1] ; Hirata, Bruna Kelly Sousa [2] ; de Andrade, Heider Mendonca [2] ; Julio, Viviane da Silva [2] ; Figueiredo Borges Ribeiro, Jessica de Souza [2] ; Cerutti, Suzete Maria [2] ; Oyama, Lila Missae [1] ; Ribeiro, Eliane Beraldi [1] ; Telles, Monica Marques [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, Rua Botucatu 862, Edificio Ciencias Biomed, 2 Andar, BR-04023062 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Ciencias Biol, Setor Fisiol & Farmacol, Diadema, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 11, n. 1 JAN 8 2021.
Web of Science Citations: 1
Abstract

While several pieces of evidence link obesity and mood disorders in menopause, the mechanisms involved are not yet fully understood. We have previously demonstrated that Ginkgo biloba extract (GbE) both attenuated diet-induced obesity of male rats and restored serotonin-induced hypophagia in ovariectomized female rats. The present study aimed at exploring whether GbE treatment ameliorates ovariectomy-related obesity and anxious/depressive-like behaviours. Wistar female rats were either ovariectomized (OVX) or sham-operated (Sham). After 2 months, either 500 mg/kg of GbE or vehicle were administered daily by gavage for 14 days. Anxious/depressive-like behaviours were assessed by the Elevated Plus Maze and the Forced Swim Tests, respectively. Ovariectomy caused high visceral adiposity, hyperleptinemia, and hypercholesterolemia, and increased the anxiety index (p=0.048 vs. Sham+GbE) while it decreased the latency to immobility (p=0.004 vs. Sham). GbE treatment in OVX rats improved body composition, adiponectin levels and blood lipid profile. It also reduced the anxiety index (p=0.004) and increased the latency to immobility (p=0.003) of OVX rats. Linear regression analysis demonstrated that leptin (p=0.047) and total cholesterol levels (p=0.022) were associated with anxious-like behaviours while body adiposity (p=0.00005) was strongly associated with depressive-like behaviours. The results showed that GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours. Further studies are warranted to better understand the therapeutic potential of GbE in menopause. (AU)

FAPESP's process: 12/03172-4 - Obesity and depression in the post-menopause: study in rats about the effects of ovariectomy on behavioral aspects and parameters of the central regulation of feeding
Grantee:Eliane Beraldi Ribeiro
Support type: Regular Research Grants