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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Illuminating the Brain With X-Rays: Contributions and Future Perspectives of High-Resolution Microtomography to Neuroscience

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Rodrigues, Paulla Vieira [1, 2] ; Tostes, Katiane [1] ; Bosque, Beatriz Pelegrini [1, 2] ; Godoy, Joao Vitor Pereira de [1, 2] ; Amorim Neto, Dionisio Pedro [1, 2] ; Dias, Carlos Sato Baraldi [3] ; Fonseca, Matheus de Castro [1]
Total Authors: 7
[1] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Campinas - Brazil
[2] Univ Estadual Campinas, Dept Struct & Funct Biol, Campinas - Brazil
[3] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Synchrotron Light Natl Lab LNLS, Campinas - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN NEUROSCIENCE; v. 15, MAR 17 2021.
Web of Science Citations: 0

The assessment of three-dimensional (3D) brain cytoarchitecture at a cellular resolution remains a great challenge in the field of neuroscience and constant development of imaging techniques has become crucial, particularly when it comes to offering direct and clear obtention of data from macro to nano scales. Magnetic resonance imaging (MRI) and electron or optical microscopy, although valuable, still face some issues such as the lack of contrast and extensive sample preparation protocols. In this context, x-ray microtomography (mu CT) has become a promising non-destructive tool for imaging a broad range of samples, from dense materials to soft biological specimens. It is a new supplemental method to be explored for deciphering the cytoarchitecture and connectivity of the brain. This review aims to bring together published works using x-ray mu CT in neurobiology in order to discuss the achievements made so far and the future of this technique for neuroscience. (AU)

FAPESP's process: 19/24511-0 - The role of LRRK2 and Rab GTPases in the neurodegeneration during sporadic Parkinson's Disease
Grantee:Beatriz Pelegrini Bosque
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/20014-0 - The gut-brain connection: role of the gut microbioma in the outcome and development of the sporadic Parkinson's disease
Grantee:Matheus de Castro Fonseca
Support Opportunities: Regular Research Grants