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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility

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Pieretti, Joana Claudio [1] ; Goncalves, Marcelly Chue [2] ; Nakazato, Gerson [2] ; Santos de Souza, Ana Carolina [1] ; Boudier, Ariane [3] ; Seabra, Amedea Barozzi [1]
Total Authors: 6
[1] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[2] Univ Estadual Londrina, Dept Microbiol, Londrina, PR - Brazil
[3] Univ Lorraine, CITHEFOR, F-54000 Nancy - France
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

The combination of Fe3O4@Ag superparamagnetic hybrid nanoparticles and nitric oxide (NO) represents an innovative strategy for a localized NO delivery with a simultaneous antibacterial and antitumoral actions. Here, we report the design of Fe3O4@Ag hybrid nanoparticles, coated with a modified and nitrosated chitosan polymer, able to release NO in a biological medium. After their synthesis, physicochemical characterization confirmed the obtention of small NO-functionalized superparamagnetic Fe3O4@Ag NPs. Antibacterial assays demonstrated enhanced effects compared to control. Bacteriostatic effect against Gram-positive strains and bactericidal effect against E. coli were demonstrated. Moreover, NO-functionalized Fe3O4@Ag NPs demonstrated improved ability to reduce cancer cells viability and less cytotoxicity against non-tumoral cells compared to Fe3O4@Ag NPs. These effects were associated to the ability of these NPs act simultaneous as cytotoxic (necrosis inductors) and cytostatic compounds inducing S-phase cell cycle arrest. NPs also demonstrated low hemolysis ratio (<10%) at ideal work range, evidencing their potential for biomedical applications. {[}GRAPHICS] . (AU)

FAPESP's process: 19/07766-5 - Blood compatibility of hybrid magnetic/silver nanoparticles coated with nitric oxide donor
Grantee:Joana Claudio Pieretti
Support Opportunities: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 18/08194-2 - Essential oil amended with metal nanoparticles functionalized with nitric oxide as a strategy to control plant pathogens in the agriculture
Grantee:Amedea Barozzi Seabra
Support Opportunities: Regular Research Grants
FAPESP's process: 18/02832-7 - Hybrid magnetic and antibacterial nanoparticles: synthesis, characterization and applications
Grantee:Joana Claudio Pieretti
Support Opportunities: Scholarships in Brazil - Master