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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Intravenous Regional Limb Perfusion in Standing and Recumbent Horses: A Comparative Radiographic Study

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Garcia, Adriana F. S. [1] ; Doria, Renata G. S. [2] ; Arantes, Julia A. [2] ; Reginato, Gustavo M. [2] ; Neubauer, Fernanda G. [3] ; Ribeiro, Gesiane [1]
Total Authors: 6
[1] United Metropolitan Coll FMU, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Pirassununga, SP - Brazil
[3] GNVETS, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Equine Veterinary Science; v. 98, MAR 2021.
Web of Science Citations: 0

Although pharmacokinetic studies of drugs administered by intravenous regional limb perfusion (IRLP) to treat equine orthopedic infections suggest efficient drug distribution in the limbs, it remains unclear whether drug perfusion is affected by the position of the horse during the procedure. This study compared the perfusion of a radiopaque contrast into tissues of the extremities of horses maintained in standing and recumbent positions during an IRLP. Radiopaque contrast was administered through IRLP into the cephalic vein of 10 healthy adult horses under general anesthesia and right lateral recumbency (RG) or under sedation and standing (SG). The same animals were used in both groups, respecting a two-week washout period. Sequential radiographic images were performed immediately at the beginning of contrast administration (T0) and after 10, 20, 30, 40, and 50 minutes. Tourniquets were removed after 30 minutes. The time required for the contrast to reach the hooves was compared between groups. Contrast reached the hooves faster in SG (114 +/- 15 seconds) compared with RG (236 +/- 29 seconds) (P < 0.5). SG showed more uniform perfusion of the limb vessels, whereas RG showed more deposition of the contrast in the lateral digital vein, with smaller amounts reaching the hooves. From T10 onward, soft tissue radiopacity increased, albeit more markedly in standing than in recumbent animals, remaining until T50. Contrast radiography evidenced that IRLP performed in standing position leads to a quicker and more uniform perfusion of the vasculature and a more noticeable diffusion to the tissues than in recumbent horses. (c) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 19/03193-0 - Transient response of inflammatory mediators induced by lipopolysaccharide in blood and allantoic fluid of pregnant mares.
Grantee:Renata Gebara Sampaio Dória
Support type: Regular Research Grants
FAPESP's process: 15/21430-9 - Evaluation of the viability of the use of totally implanted catheter in equine limbs
Grantee:Renata Gebara Sampaio Dória
Support type: Regular Research Grants