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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hypothalamic Microglial Heterogeneity and Signature under High Fat Diet-Induced Inflammation

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Mendes, Natalia Ferreira [1, 2] ; Jara, Carlos Poblete [1, 2] ; Zanesco, Ariane Maria [2, 3] ; de Araujo, Eliana Pereira [1, 2]
Total Authors: 4
[1] Univ Estadual Campinas, Fac Nursing, BR-13083887 Campinas - Brazil
[2] Univ Estadual Campinas, Lab Cell Signaling, Obes & Comorbid Res Ctr, BR-13083864 Campinas - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, BR-13083887 Campinas - Brazil
Total Affiliations: 3
Document type: Review article
Web of Science Citations: 3

Under high-fat feeding, the hypothalamus atypically undergoes pro-inflammatory signaling activation. Recent data from transcriptomic analysis of microglia from rodents and humans has allowed the identification of several microglial subpopulations throughout the brain. Numerous studies have clarified the roles of these cells in hypothalamic inflammation, but how each microglial subset plays its functions upon inflammatory stimuli remains unexplored. Fortunately, these data unveiling microglial heterogeneity have triggered the development of novel experimental models for studying the roles and characteristics of each microglial subtype. In this review, we explore microglial heterogeneity in the hypothalamus and their crosstalk with astrocytes under high fat diet-induced inflammation. We present novel currently available ex vivo and in vivo experimental models that can be useful when designing a new research project in this field of study. Last, we examine the transcriptomic data already published to identify how the hypothalamic microglial signature changes upon short-term and prolonged high-fat feeding. (AU)

FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 16/17810-3 - Evaluation of TGF-b1 function in the hypothalamus of animals with obesity and diabetes induced by high-fat diet
Grantee:Natália Ferreira Mendes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/22511-8 - Role of microglial cells in the high-fat diet-induced hypothalamic inflammation
Grantee:Natália Ferreira Mendes
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 19/00330-7 - Effect of palmitate treatment in pc1/3 expression in a hypothalamic cell lineage
Grantee:Ariane Maria Zanesco
Support type: Scholarships in Brazil - Master