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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protein restriction during puberty alters nutritional parameters and affects ovarian and uterine histomorphometry in adulthood in rats

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de Morais Oliveira, Diego Augusto [1, 2] ; Lupi, Luiz Antonio [1] ; Silveira, Henrique Spaulonci [1] ; de Almeida Chuffa, Luiz Gustavo [1]
Total Authors: 4
[1] UNESP Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Inst Biosci Botucatu, Grad Program Nutr, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Experimental Pathology; v. 102, n. 2, p. 93-104, APR 2021.
Web of Science Citations: 0

In a large part of the population inefficient ingestion of proteins, whether for cultural, aesthetic or economic reasons, is a global concern. Low-protein diets can cause severe functional complications, mainly during the development and maturation of organs and systems, including the female reproductive system. The present study investigated the effect of nutritional protein restriction during puberty on the oestrous cycle and expression of sex steroid receptors (AR, ER alpha e ER beta) in ovarian and uterine tissues of adult rats. Protein restriction promoted lower body weight gain, feed efficiency and higher caloric intake. There was an increase in the oestrus phase arrest without changing the total length of the oestrous cycle. The consumption of low-protein diet also reduced the thickness of the uterine endometrium (uterine epithelium and endometrial stroma) in addition to increasing the number of primary and atretic follicles in the ovaries. Furthermore, the low-protein diet reduced the levels of androgen receptor (AR) and increased the oestrogen receptor beta (ER beta) in the ovary, while no significant changes were observed in the uterus. Our study reinforces the importance of adequate protein intake during puberty, since physiological changes in this developmental period interfere with the histomorphometry of the ovaries and uteri, possibly resulting in impaired folliculogenesis and fertility in the reproductive period. (AU)

FAPESP's process: 18/09243-7 - Impact of the protein restriction on estrous cycle and sex steroid receptors in the ovaries and uteri of juvenile rats
Grantee:Diego Augusto de Morais Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/00906-6 - Melatonin and the MT1 and MT2 receptors: effects on apoptosis, cell proliferation and migratory potential of the ovarian carcinoma cells (SKOV-3 cell line)
Grantee:Luiz Gustavo de Almeida Chuffa
Support Opportunities: Regular Research Grants