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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Elderly Subjects Supplemented with L-Glutamine Shows an Improvement of Mucosal Immunity in the Upper Airways in Response to Influenza Virus Vaccination

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Paixao, Vitoria [1] ; Almeida, Ewin B. [1] ; Amaral, Jonatas B. [1] ; Roseira, Tamaris [2, 1] ; Monteiro, Fernanda R. [2, 1] ; Foster, Roberta [2, 1] ; Sperandio, Adriane [2] ; Rossi, Marcelo [1] ; Amirato, Gislene R. [1] ; Santos, Carlos A. F. [3] ; Pires, Renier S. [4] ; Leal, Fabyano B. [5] ; Durigon, Edison L. [5, 6] ; Oliveira, Danielle B. L. [7, 5] ; Vieira, Rodolfo P. [8, 9, 10] ; Vaisberg, Mauro [1] ; Santos, Juliana M. B. [10] ; Bachi, Andre L. L. [8, 1, 4]
Total Authors: 18
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Dept Otorhinolaryngol, ENT Lab, BR-04021001 Sao Paulo - Brazil
[2] Method Fac Sao Paulo FAMESP, BR-04046200 Sao Paulo - Brazil
[3] Paulista Sch Med EPM, Dept Med, Geriatry, BR-04023062 Sao Paulo - Brazil
[4] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, BR-04743030 Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, BR-05508060 Sao Paulo - Brazil
[6] Univ Sao Paulo, Sci Platform Pasteur, BR-05508060 Sao Paulo - Brazil
[7] Hosp Israelita Albert Einstein, BR-05652900 Sao Paulo - Brazil
[8] Brazilian Inst Teaching & Res Pulm & Exercise Imm, BR-12245520 Sao Paulo - Brazil
[9] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, BR-15600000 Sao Paulo - Brazil
[10] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human & Rehabil, BR-11015020 Santos, SP - Brazil
Total Affiliations: 10
Document type: Journal article
Source: VACCINES; v. 9, n. 2 FEB 2021.
Web of Science Citations: 1
Abstract

Background: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. Methods: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). Results: Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-alpha levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. Conclusion: Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects. (AU)

FAPESP's process: 19/13188-4 - Study of the effects of glutamine supplementation on the immunophenotyping and activation profile of t and b lymphocytes from practicing or NON-EXERCISING seniors submitted to influenza virus vaccination
Grantee:Tamaris Roseira dos Reis Pavao
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/13094-0 - Evaluation of the influence of combined physical exercise and L-glutamine supplementation on the inflammatory profile and response of specific antibodies to the vaccine against the influenza virus in elderly people
Grantee:Fernanda Rodrigues Monteiro
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals
Grantee:Rodolfo de Paula Vieira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/14115-0 - Influence of L-glutamine supplementation in the sarcopenia and immune/inflammatory response both systemic and in the respiratory tract of elderly practitioners or not of a regular program of combined physical exercises submitted to Influenza virus vaccine
Grantee:André Luis Lacerda Bachi
Support Opportunities: Regular Research Grants