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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

kappa-Opioid receptors in the medial amygdaloid nucleus modulate autonomic and neuroendocrine responses to acute stress

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Fassini, Aline [1] ; Scopinho, America A. [1] ; Fortaleza, Eduardo A. T. [1] ; Resstel, Leonardo B. M. [1] ; Correa, Fernando M. A. [1]
Total Authors: 5
[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: European Neuropsychopharmacology; v. 43, p. 25-37, FEB 2021.
Web of Science Citations: 0

The medial amygdaloid nucleus (MeA) is a key neural structure in triggering physiologic and behavioral control during aversive situations. However, MeA role during stress exposure has not yet been fully elucidated. Thus, in the present study, we investigated the involvement of the MeA opioid neurotransmission in the modulation of autonomic, neuroendocrine and behavioral responses evoked by acute restraint stress (RS). The bilateral microinjection of naloxone (non-selective opioid antagonist) into the MeA potentiated RS-evoked autonomic responses and increased plasma corticosterone levels, in a dose-dependent manner. However, no effects were observed in RS-evoked increases on plasma oxytocin levels and anxiogenic-like behavior. Similar to naloxone, MeA pretreatment with the selective kappa-opioid antagonist (nor-BNI) also enhanced heart rate and corticosterone increases induced by RS, whereas treatment with selective mu- or delta-opioid antagonists did not affect the physiologic and behavioral responses caused by RS. The present results showed MeA kappa-opioid receptors modulate heart rate and corticosterone increases evoked by acute RS, reinforcing the idea of an inhibitory role exerted by MeA during aversive situations. (c) 2020 Elsevier B.V. and ECNP. All rights reserved. (AU)

FAPESP's process: 13/13721-8 - Study of the involvement of endocannabinoid system into the prefrontal medial córtex on food intake of rats.
Grantee:América Scopinho Augusto
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/09300-4 - Bed nucleus of the stria terminalis noradrenergic system modulates contextual fear conditionig: possible interaction with CRF and glutamatergic and nitrergic neurotransmission
Grantee:Leonardo Resstel Barbosa Moraes
Support type: Regular Research Grants
FAPESP's process: 12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders
Grantee:Francisco Silveira Guimaraes
Support type: Research Projects - Thematic Grants