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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children

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Souza, Livia Victorino [1] ; de Almeida, Sandro Soares [2] ; De Meneck, Franciele [1] ; Thomazini, Fernanda [3] ; Araujo, Ronaldo Carvalho [4] ; Franco do, Maria Carmo [1]
Total Authors: 6
[1] Univ Fed Sao Paulo, Sch Med, Med Dept, Div Nephrol, Sao Paulo - Brazil
[2] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Sch Med, Div Translat Med, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Sch Med, Biophys Dept, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Peptides; v. 137, MAR 2021.
Web of Science Citations: 0

Previous reports reveal that +9/-9 polymorphism of the bradykinin B2 receptor (BDKRB2) is suggestive of cardiometabolic diseases. The aim of this study was to examine the impact of BDKRB2 + 9/-9 polymorphism genotypes on the blood pressure parameters and microvascular function in prepubescent children. We screened for BDKRB2 + 9/-9 polymorphism in the DNA of 145 children (86 boys and 59 girls), and its association with body composition, blood pressure levels, biochemical parameters, and endothelial function was determined. No significant association of the BDKRB2 genotypes with gender (P=0.377), race (P=0.949) or family history of cardiovascular disease (CVD) (P=0.858) was observed. Moreover, we did not identify any interaction between BDKRB2 genotypes with a phenotype of obesity (P=0.144). Children carrying the +9/+9 genotype exhibited a significant linear trend with higher levels of systolic blood pressure and pulse pressure (P < 0.001). Moreover, the presence of +9 allele resulted in a decrease of reactive hyperemia index, showing a decreasing linear trend from -9/-9 to +9/+9, wherein this parameter of endothelial function was the lowest in the +9/+9 children, intermediate in the +9/-9 children, and the highest in the -9/-9 children (P< 0.001). There was a significant inverse correlation between reactive hyperemia index and systolic blood pressure (r= - 0.348, P< 0.001) and pulse pressure (r= - 0.399, P< 0.001). Our findings indicate that the +9/+9 BDKRB2 genotype was associated with high blood pressure and microvascular dysfunction in prepubescent Brazilian children. (AU)

FAPESP's process: 18/04013-3 - Quantification of the endothelial microparticles and analysis of the miRNA profile: evaluation of the impact on the interrelation between birth weight, blood pressure levels and endothelial function in children from 6 to 12 years of age
Grantee:Maria Do Carmo Pinho Franco
Support Opportunities: Regular Research Grants
FAPESP's process: 17/08361-3 - Evaluating recreational physical exercise, birth weight, pressure levels and components of renin-angiotensin-kallikrein-kinin system interactions in children
Grantee:Livia Victorino de Souza
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/20082-7 - Kallikrein kinin system in physical exercise and metabolism
Grantee:Ronaldo de Carvalho Araújo
Support Opportunities: Research Projects - Thematic Grants