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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronic Escitalopram Treatment Does Not Alter the Effects of Neonatal Stress on Hippocampal BDNF Levels, 5-HT(1A)Expression and Emotional Behaviour of Male and Female Adolescent Rats

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Henn, Lorena [1] ; Zanta, Natalia C. [1] ; Girardi, Carlos Eduardo N. [1] ; Suchecki, Deborah [1]
Total Authors: 4
[1] Univ Fed Sao Paulo, Dept Psicobiol, Rua Napoleao Barros 925, 1 Andar, BR-04024002 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Molecular Neurobiology; v. 58, n. 3, p. 926-943, MAR 2021.
Web of Science Citations: 0

Early life stress is considered a risk factor for the development of long-term psychiatric disorders. Maternal deprivation (MD) is a useful paradigm to understand the neurobiological underpinnings of early stress-induced changes in neurodevelopment trajectory. The goal of the present study was to examine the effects of a chronic treatment with escitalopram (ESC) on the hippocampal levels of BDNF and neuropeptide Y (NPY), expression of serotonin type 1A receptor (5-HT1A), plasma corticosterone levels and emotional behaviours in male and female adolescent rats submitted to MD at 9 days of life (group DEP9) and challenged with a brief and mild stress (saline injection (SAL)) at the end of MD. Whole litters were kept with mothers (CTL) or submitted to MD (DEP9). Within each group, pups were stress-challenged (CTL-SAL and DEP9-SAL) or not (CTL-NSAL and DEP9-NSAL). ESC or vehicle treatments began at weaning and lasted 24 days, when animals were sacrificed for determination of neurobiological variables or submitted to a battery of tests for evaluation of emotional behaviours. The results showed that BDNF levels were higher in SAL-challenged males and in DEP9-SAL females, whereas 5-HT(1A)receptor expression was reduced in DEP9 males and in SAL-challenged females. There were no changes in NPY or corticosterone levels. In the forced swim test, SAL-challenged males and DEP9 females displayed less immobility and ESC only increased social motivation in males. The results indicated that neonatal stress led to sex-dependent changes in neurobiology and behaviour and that chronic ESC treatment had minor effects on these parameters. (AU)

FAPESP's process: 15/24745-0 - Effect of treatment with escitalopram on behavioral alterations resulting from maternal deprivation at postnatal day 9 in Wistar rats
Grantee:Natália Cristina Zanta
Support type: Scholarships in Brazil - Master
FAPESP's process: 15/26364-4 - Neurobiologic mechanisms involved in the long-term emotional effects of maternal deprivation
Grantee:Deborah Suchecki
Support type: Regular Research Grants