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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neurobiology of glycine transporters: From molecules to behavior

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Marques, Bruno Lemes [1] ; Oliveira-Lima, Onesia Cristina [1] ; Carvalho, Gustavo Almeida [1] ; Chiarelli, Raphaela de Almeida [1] ; Ribeiro, Raul Izidoro [1] ; Parreira, Ricardo Cambraia [1] ; da Madeira Freitas, Elis Marra [1] ; Resende, Rodrigo Ribeiro [2] ; Klempin, Friederike [3] ; Ulrich, Henning [4] ; Gomez, Renato Santiago [5] ; Xavier Pinto, Mauro Cunha [1]
Total Authors: 12
[1] Univ Fed Goias, Inst Ciencias Biol, Lab Neuroquim & Neurofarmacol Neurolab, Goiania, Go - Brazil
[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[3] Max Delbruck Ctr Mol Med, Berlin - Germany
[4] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP - Brazil
[5] Univ Fed Minas Gerais, Fac Med, Dept Cirurgia, Belo Horizonte, MG - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 0

Glycine transporters (GlyTs) are Na+/Cl--dependent neurotransmitter transporters, responsible for L-glycine uptake into the central nervous system. GlyTs are members of the solute carrier family 6 (SLC6) and comprise glycine transporter type 1 (SLC6A9; GlyT1) and glycine transporter type 2 (SLC6A5; Glyt2). GlyT1 and GlyT2 are expressed on both astrocytes and neurons, but their expression pattern in brain tissue is foremost related to neurotransmission. GlyT2 is markedly expressed in brainstem, spinal cord and cerebellum, where it is responsible for glycine uptake into glycinergic and GABAergic terminals. GlyT1 is abundant in neocortex, thalamus and hippocampus, where it is expressed in astrocytes, and involved in glutamatergic neurotransmission. Consequently, inhibition of GlyT1 transporters can modulate glutamatergic neurotransmission through NMDA receptors, suggesting an alternative therapeutic strategy. In this review, we focus on recent progress in the understanding of GlyTs role in brain function and in various diseases, such as epilepsy, hyperekplexia, neuropathic pain, drug addiction, schizophrenia and stroke, as well as in neurodegenerative disorders. (AU)

FAPESP's process: 18/08426-0 - Indole alkaloid sub products of Maqui (Aristotelia chilensis) processing as food additives to Alzheimer's Disease treatment
Grantee:Alexander Henning Ulrich
Support Opportunities: Regular Research Grants