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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphisms and haplotypes in the Interleukin 17 Alfa gene: potential effect of smoking habits in the association with periodontitis and type 2 diabetes mellitus

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Author(s):
Rimachi Hidalgo, Marco A. [1, 2] ; Cirelli, Thamiris [1, 2] ; da Silva, Barbara Roque [1, 2] ; Nicchio, Ingra Gagno [1, 2] ; Nepomuceno, Rafael [1, 2] ; Orrico, Silvana R. P. [1, 3] ; Cirelli, Joni A. [1] ; Theodoro, Leticia Helena [1] ; Barros, Silvana P. [4] ; Scarel-Caminaga, Raquel M. [2]
Total Authors: 10
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Morphol & Pediat Clin, Araraquara, SP - Brazil
[3] Union Coll Great Lakes UNILAGO, Adv Res Ctr Med, BR-15030070 Sao Jose Do Rio Preto, SP - Brazil
[4] Univ North Carolina Chapel Hill UNC, Sch Dent, Dept Periodontol, Chapel Hill, NC - USA
Total Affiliations: 4
Document type: Journal article
Source: MOLECULAR BIOLOGY REPORTS; v. 48, n. 2 FEB 2021.
Web of Science Citations: 0
Abstract

Few studies evaluate interrelationships between periodontitis (P) and Type 2 Diabetes Mellitus (T2DM). The aim of this study is to investigate the genetic susceptibility to periodontitis alone, or concomitant with T2DM (as comorbidities), analyzing single nucleotide polymorphisms (SNPs) in the Interleukin 17 alpha (IL17A) gene, considering the biochemical profile and smoking habits on the subjects' periodontal status. We investigated 879 individuals divided into: T2DM subjects also affected by severe or moderate periodontitis (T2DM-P, n = 199); non-diabetics with severe or moderate periodontitis (PERIODONTITIS, n = 342); and healthy subjects (HEALTHY, n = 338). Subjects underwent complete periodontal examination, history of smoking habits, glycemic and lipid biochemical evaluation. DNA from buccal cells was utilized to genotype the SNPs rs2275913, rs3819024 and rs10484879. The impact of the subjects' biochemical profile was analyzed in their periodontal status. Each SNP was analyzed independently, and as haplotypes, by multiple logistic regressions, adjusted for covariates, and also stratifying the groups by age, sex and smoking habits. Independently of the periodontitis degree, poorly-controlled T2DM subjects showed worse glycemic and lipid profile. Multiple logistic regressions demonstrated that smokers and former-smokers carrying the GG genotype of rs3819024 seemed to have higher risk for T2DM-Periodontitis (OR = 6.33; 95% CI = 1.26-31.77, p = 0.02), and mainly for T2DM alone (OR = 5.11; 95% CI = 1.37-19.06, p = 0.01), than never smokers. We found the potential effect of smoking habits in the association of IL17A-rs3819024-GG with diseased phenotypes. Because the observed wide confidence intervals, further studies enrolling larger populations, and SNPs' functional evaluations are needed to better understand our findings. (AU)

FAPESP's process: 18/26367-1 - Investigation of polymorphs in the DEFB1 gene with susceptibility to chronic periodontal disease and type 2 diabetes mellitus
Grantee:Ana Cláudia dos Santos Rios
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 16/03753-8 - Investigation of potential genetic markers of chronic periodontitis associated or not with type 2 diabetes mellitus through patient's genetic susceptibility and both glycemic and lipid profiles
Grantee:Raquel Mantuaneli Scarel Caminaga
Support type: Regular Research Grants
FAPESP's process: 16/08070-6 - Investigation of genetic susceptibility to chronic periodontitis associated with Type 2 Diabetes mellitus
Grantee:Thamiris Cirelli
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/18313-3 - Investigation of genetic variations susceptibility to chronic periodontitis by OpenArray®: Biostatistics, Bioinformatics and Functional Analysis
Grantee:Rafael Nepomuceno Oliveira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/13295-1 - Investigation of the association of genetic variation regarding susceptibility to chronic periodontal disease by OpenArray
Grantee:Rafael Nepomuceno Oliveira
Support type: Scholarships in Brazil - Doctorate