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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Breath Biopsy and Discovery of Exclusive Volatile Organic Compounds for Diagnosis of Infectious Diseases

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Belizario, Jose E. [1] ; Faintuch, Joel [2] ; Malpartida, Miguel Garay [3]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Arts Sci & Humanities EACH, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Web of Science Citations: 0

Exhaled breath contains thousand metabolites and volatile organic compounds (VOCs) that originated from both respiratory tract and internal organ systems and their microbiomes. Commensal and pathogenic bacteria and virus of microbiomes are capable of producing VOCs of different chemical classes, and some of them may serve as biomarkers for installation and progression of various common human diseases. Here we describe qualitative and quantitative methods for measuring VOC fingerprints generated by cellular and microbial metabolic and pathologic pathways. We describe different chemical classes of VOCs and their role in the host cell-microbial interactions and their impact on infection disease pathology. We also update on recent progress on VOC signatures emitted by isolated bacterial species and microbiomes, and VOCs identified in exhaled breath of patients with respiratory tract and gastrointestinal diseases, and inflammatory syndromes, including the acute respiratory distress syndrome and sepsis. The VOC curated databases and instrumentations have been developed through statistically robust breathomic research in large patient populations. Scientists have now the opportunity to find potential biomarkers for both triage and diagnosis of particular human disease. (AU)

FAPESP's process: 07/04513-1 - Induction of apoptosis or cell proliferation in breast and prostate tumor cell lines by the novel cytokine PANDER
Grantee:Humberto Miguel Garay Malpartida
Support type: Regular Research Grants
FAPESP's process: 15/18647-6 - Human microbiomes and their roles in dysbiosis, common diseases and novel therapeutic approaches
Grantee:José Ernesto Belizario
Support type: Regular Research Grants - Publications - Scientific article