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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Therapeutic Potential of Photobiomodulation In Alzheimer's Disease: A Systematic Review

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Cardoso, Fabrizio dos Santos [1] ; Brandao Lopes Martins, Rodrigo Alvaro [2] ; da Silva, Sergio Gomes [1, 3, 4]
Total Authors: 3
[1] Univ Mogi das Cruzes UMC, Mogi Das Cruzes, SP - Brazil
[2] Univ Vale Paraiba UNIVAP, Sao Jose Dos Campos, SP - Brazil
[3] Ctr Univ UNIFAMINAS, Belo Horizonte, MG - Brazil
[4] Hosp Canc Muriae, Fundacao Cristiano Varella, Muriae, MG - Brazil
Total Affiliations: 4
Document type: Review article
Source: JOURNAL OF LASERS IN MEDICAL SCIENCES; v. 11, n. 4, 1, p. S16-S22, FAL 2020.
Web of Science Citations: 0

Introduction: Alzheimer disease (AD) is characterized by the decline of cognitive functions such as learning and memory. Scientific society has proposed some non-pharmacological interventions, among which photobiomodulation has gained prominence for its beneficial effects. Therefore, we investigated, through systematic review, the therapeutic potential of photobiomodulation in AD. Methods: This systematic review was registered under the number CRD42019128416 in the International Prospective Record of Systematic Reviews (PROSPERO). A systematic search was conducted on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: ``photobiomodulation therapy{''} or ``low-level laser therapy{''} or ``LLLT{''} or ``light emitting diode{''} and ``amyloid{''} or ``Alzheimer{''}. The data search was conducted from 2008 to 2019. We follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The search strategy included experimental in vivo and in vitro studies in the English language and photobiomodulation as a non-pharmacological intervention. We included 10 studies, being 5 in vivo studies, 4 in vitro studies and 1 study using in vivo and in vitro. To evaluate the quality of the studies, we used the Rob tool of the Systematic Review Center for Laboratory Animal Experimentation (SYRLE). Results: The studies showed that photobiomodulation is able to reduce inflammatory response, oxidative stress and apoptotic effects generated by amyloid beta (A beta) and restore mitochondrial function and cognitive behavior. Conclusion: Taken together, these results indicate that photobiomodulation may be a useful tool for treating AD. (AU)

FAPESP's process: 17/16443-0 - Therapeutic potential of low-level laser in the brain of aged rats
Grantee:Fabrízio dos Santos Cardoso
Support type: Scholarships in Brazil - Doctorate