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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015-2019

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Author(s):
Dieng, Idrissa [1] ; dos Passos Cunha, Marielton [2] ; Diagne, Moussa Moise [1] ; Sembene, Pape Mbacke [3, 4] ; de Andrade Zanotto, Paolo Marinho [2] ; Faye, Ousmane [1] ; Faye, Oumar [1] ; Sall, Amadou Alpha [1]
Total Authors: 8
Affiliation:
[1] Inst Pasteur, Virol Dept, Arboviruses & Haemorrhag Fever Viruses Unit, BP 220, Dakar - Senegal
[2] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, BR-05508000 Sao Paulo - Brazil
[3] Univ Cheikh Anta Diop Dakar UCAD, Fac Sci & Tech, Dept Anim Biol, Fann BP 5005, Dakar - Senegal
[4] UCAD, ISRA, CBGP, BIOPASS, IRD, Campus Bel Air, BP 1386, Dakar 18524 - Senegal
Total Affiliations: 4
Document type: Journal article
Source: Viruses-Basel; v. 13, n. 1 JAN 2021.
Web of Science Citations: 0
Abstract

Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015-2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88-2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia. (AU)

FAPESP's process: 16/08204-2 - Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016
Grantee:Marielton dos Passos Cunha
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/23281-6 - The use of antibodies that neutralize infection at a post-attachment step for the development of innovative immunotherapeutic strategies exemplified for selective destruction of Zika-infected human cells.
Grantee:Paolo Marinho de Andrade Zanotto
Support Opportunities: Regular Research Grants