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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dexamethasone Does Not Inhibit Treadmill Training-Induced Angiogenesis in Myocardium: Role of MicroRNA-126 Pathway

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Herrera, Naiara A. [1] ; Duchatsch, Francine [1] ; Tardelli, Lidieli P. [1] ; Dionisio, Thiago J. [2] ; Santos, Carlos F. [2] ; Amaral, Sandra L. [3, 1]
Total Authors: 6
[1] PIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
[3] Sao Paulo State Univ Unesp, Sch Sci, Dept Phys Educ, Bauru, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Cardiovascular Pharmacology; v. 76, n. 6, p. 708-714, DEC 2020.
Web of Science Citations: 1

Dexamethasone (DEX) has important anti-inflammatory activities; however, it induces hypertension and skeletal muscle microcirculation rarefaction. Nevertheless, nothing is known about DEX outcomes on cardiac microcirculation. By contrast, exercise training prevents skeletal and cardiac microvessel loss because of microRNA expression and a better balance between their related angiogenic and apoptotic proteins in spontaneously hypertensive rats. The purpose of this study was to investigate whether DEX and/or exercise training could induce microRNA alterations leading to cardiac angiogenesis or microvascular rarefaction. Animals performed 8 weeks of exercise training and were treated with DEX (50 mu g/kg per day, subcutaneously) for 14 days. Cardiovascular parameters were measured, and the left ventricle muscle was collected for analyses. DEX treatment increased arterial pressure and did not cause cardiac microcirculation rarefaction. Treadmill training prevented the DEX-induced increase in arterial pressure. In addition, training, regardless of DEX treatment, increased microRNA-126 expression, phospho-protein kinase B/protein kinase B, and endothelial nitric oxide synthase levels associated with cardiac angiogenesis. In conclusion, this study suggests, for the first time, that treadmill training induces myocardial angiogenesis because of angiogenic pathway improvement associated with an increase in microRNA-126. Furthermore, DEX, per se, did not cause capillary density alterations and did not attenuate cardiac angiogenesis induced by training. (AU)

FAPESP's process: 17/00509-1 - Role of physical training on autonomic balance, arterial stiffness and rarefaction in spontaneously hypertensive rats treated with dexamethasone: role of miRNA
Grantee:Sandra Lia do Amaral Cardoso
Support type: Regular Research Grants
FAPESP's process: 15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach
Grantee:Carlos Ferreira dos Santos
Support type: Research Projects - Thematic Grants
Grantee:Naiara Araújo Herrera
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/12532-5 - Exercise training effects on SHR treated with dexamethasone: role of miRNAs
Grantee:Naiara Araújo Herrera
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/14405-3 - Influence of aerobic physical training on cardiac remodeling of spontaneously hypertensive rats treated with dexamethasone
Grantee:Francine Duchatsch Ribeiro de Souza
Support type: Scholarships in Brazil - Master