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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immune Sensing and Potential Immunotherapeutic Approaches to Control Chromoblastomycosis

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Author(s):
Breda, Leandro C. D. [1] ; Menezes, Isabela G. [1] ; Paulo, Larissa N. M. [1] ; de Almeida, Sandro Rogerio [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: JOURNAL OF FUNGI; v. 7, n. 1 JAN 2021.
Web of Science Citations: 0
Abstract

Chromoblastomycosis (CBM) is a neglected, chronic, and progressive subcutaneous mycosis caused by different species of fungi from the Herpotrichiellaceae family. CBM disease is usually associated with agricultural activities, and its infection is characterized by verrucous, erythematous papules, and atrophic lesions on the upper and lower limbs, leading to social stigma and impacts on patients' welfare. The economic aspect of disease treatment is another relevant issue. There is no specific treatment for CBM, and different anti-fungal drug associations are used to treat the patients. However, the long period of the disease and the high cost of the treatment lead to treatment interruption and, consequently, relapse of the disease. In previous years, great progress had been made in the comprehension of the CBM pathophysiology. In this review, we discuss the differences in the cell wall composition of conidia, hyphae, and muriform cells, with a particular focus on the activation of the host immune response. We also highlight the importance of studies about the host skin immunology in CBM. Finally, we explore different immunotherapeutic studies, highlighting the importance of these approaches for future treatment strategies for CBM. (AU)

FAPESP's process: 18/11624-9 - Identification of immunogenic peptides of Fonsecaea pedrosoi and its possible use as vaccine in the experimental chromoblastomycosis
Grantee:Isabela de Godoy Menezes
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/18598-7 - Role of pattern recognition receptors (PRRs) in the activation of macrophages in cutaneous fungal infections caused by Fonsecaea pedrosoi, Sporothrix schenckii and Trichophyton rubrum
Grantee:Sandro Rogerio de Almeida
Support type: Research Projects - Thematic Grants
FAPESP's process: 19/14347-9 - Macrophages and neutrophils' effector function and metabolism over Fonseca pedrosoi infection
Grantee:Leandro Carvalho Dantas Breda
Support type: Scholarships in Brazil - Post-Doctorate