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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association of type 2 diabetes mellitus and periodontal disease susceptibility with genome-wide association-identified risk variants in a Southeastern Brazilian population

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Cirelli, Thamiris [1, 2] ; Nepomuceno, Rafael [1, 2] ; Goveia, Jessica Marina [2] ; Orrico, Silvana R. P. [1, 3] ; Cirelli, Joni A. [1] ; Theodoro, Leticia Helena [4] ; Barros, Silvana P. [5] ; Scarel-Caminaga, Raquel M. [2]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Morphol Genet Orthodont & Pediat Dent, Araraquara, SP - Brazil
[3] Union Coll Great Lakes UNILAGO, Sao Jose Dos Campos, SP - Brazil
[4] Sao Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Surg & Integrated Clin, Aracatuba, SP - Brazil
[5] Univ North Carolina Chapel Hill UNC, Sch Dent, Dept Comprehens Oral Hlth Periodontol, Chapel Hill, NC - USA
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 0

Objective Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to evaluate them as genetic risk variants for these diseases in the Brazilian population. Material and methods Periodontal, glycemic, and lipid data were obtained from 931 individuals divided into: control (n = 334), periodontitis (P; n = 358), and periodontitis associated with T2DM (P + T2DM; n = 239). After genotyping, associations between polymorphisms and pathologies were tested by multiple logistic and linear regressions, adjusting for age, sex, and smoking habits. Results Considering the studied subjects, the increased risk to develop periodontitis in the periodontitis P + T2DM group was found for HNF1A-rs7957197-TA, CDKAL1-rs7754840-CG, RPSAP52-rs1531343-GC, TCF7L2-rs7903146-TT, and CDKN2B-rs7018475-GG. The association of these genetic variants for TCF7L2 and CDKN2B was confirmed for female, never smokers, and poorly controlled P + T2DM. CDKN2B-rs7018475 was associated with worse glycemic condition and periodontal parameters. Conclusion These five reported genetic variants were associated in the studied Southeastern Brazilian population as genetic risk variants of periodontitis and T2DM associated to periodontitis as comorbidity. Gene-phenotype associations with sex and smoking habits and the CDKN2B-rs7018475 with the poor glycemic control and more severe periodontal conditions should be further investigated. (AU)

FAPESP's process: 18/26367-1 - Investigation of polymorphs in the DEFB1 gene with susceptibility to chronic periodontal disease and type 2 diabetes mellitus
Grantee:Ana Cláudia dos Santos Rios
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 14/13295-1 - Investigation of the association of genetic variation regarding susceptibility to chronic periodontal disease by OpenArray
Grantee:Rafael Nepomuceno Oliveira
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/18313-3 - Investigation of genetic variations susceptibility to chronic periodontitis by OpenArray®: Biostatistics, Bioinformatics and Functional Analysis
Grantee:Rafael Nepomuceno Oliveira
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/08070-6 - Investigation of genetic susceptibility to chronic periodontitis associated with Type 2 Diabetes mellitus
Grantee:Thamiris Cirelli
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/03753-8 - Investigation of potential genetic markers of chronic periodontitis associated or not with type 2 diabetes mellitus through patient's genetic susceptibility and both glycemic and lipid profiles
Grantee:Raquel Mantuaneli Scarel Caminaga
Support type: Regular Research Grants