Goveia, Jessica Marina
Orrico, Silvana R. P.
Cirelli, Joni A.
Theodoro, Leticia Helena
Barros, Silvana P.
Scarel-Caminaga, Raquel M.
Total Authors: 8
 Sao Paulo State Univ UNESP, Dept Diag & Surg, Sch Dent Araraquara, Araraquara, SP - Brazil
 Sao Paulo State Univ UNESP, Sch Dent Araraquara, Dept Morphol Genet Orthodont & Pediat Dent, Araraquara, SP - Brazil
 Union Coll Great Lakes UNILAGO, Sao Jose Dos Campos, SP - Brazil
 Sao Paulo State Univ UNESP, Sch Dent Aracatuba, Dept Surg & Integrated Clin, Aracatuba, SP - Brazil
 Univ North Carolina Chapel Hill UNC, Sch Dent, Dept Comprehens Oral Hlth Periodontol, Chapel Hill, NC - USA
Total Affiliations: 5
CLINICAL ORAL INVESTIGATIONS;
Web of Science Citations:
Objective Genome-wide association studies (GWAS) and literature have identified polymorphisms in the KCNJ11, HNF1A, IRS1, TCF7L2, CDKAL1, CDKN2B, RPSAP52, GPR45 HHEX, IL18, and RUNX2 genes associated with type 2 diabetes mellitus (T2DM) and/or periodontitis (P) in diverse populations, and we sought to evaluate them as genetic risk variants for these diseases in the Brazilian population. Material and methods Periodontal, glycemic, and lipid data were obtained from 931 individuals divided into: control (n = 334), periodontitis (P; n = 358), and periodontitis associated with T2DM (P + T2DM; n = 239). After genotyping, associations between polymorphisms and pathologies were tested by multiple logistic and linear regressions, adjusting for age, sex, and smoking habits. Results Considering the studied subjects, the increased risk to develop periodontitis in the periodontitis P + T2DM group was found for HNF1A-rs7957197-TA, CDKAL1-rs7754840-CG, RPSAP52-rs1531343-GC, TCF7L2-rs7903146-TT, and CDKN2B-rs7018475-GG. The association of these genetic variants for TCF7L2 and CDKN2B was confirmed for female, never smokers, and poorly controlled P + T2DM. CDKN2B-rs7018475 was associated with worse glycemic condition and periodontal parameters. Conclusion These five reported genetic variants were associated in the studied Southeastern Brazilian population as genetic risk variants of periodontitis and T2DM associated to periodontitis as comorbidity. Gene-phenotype associations with sex and smoking habits and the CDKN2B-rs7018475 with the poor glycemic control and more severe periodontal conditions should be further investigated. (AU)