Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mesenchymal stem cell-glioblastoma interactions mediated via kinin receptors unveiled by cytometry

Full text
Pillat, Micheli Mainardi [1] ; Oliveira-Giacomelli, Agatha [2] ; das Neves Oliveira, Mona [3] ; Andrejew, Roberta [2] ; Turrini, Natalia [2] ; Baranova, Juliana [2] ; Lah Turnsek, Tamara [4] ; Ulrich, Henning [2]
Total Authors: 8
[1] Univ Fed Santa Maria, Hlth Sci Ctr, Dept Microbiol & Parasitol, Santa Maria, RS - Brazil
[2] Univ Sao Paulo, Inst Chem, Dept Biochem, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
[3] Biolinker Synthet Biol Ltd, Sao Paulo - Brazil
[4] Natl Inst Biol, Dept Genet Toxicol & Canc Biol, Ljubljana - Slovenia
Total Affiliations: 4
Document type: Review article
Source: Cytometry Part A; v. 99, n. 2, SI JAN 2021.
Web of Science Citations: 0

Glioblastoma (GBM) is one of the most malignant and devastating brain tumors. The presence of highly therapy-resistant GBM cell subpopulations within the tumor mass, rapid invasion into brain tissues and reciprocal interactions with stromal cells in the tumor microenvironment contributes to an inevitable fatal prognosis for the patients. We highlight the most recent evidence of GBM cell crosstalk with mesenchymal stem cells (MSCs), which occurs either by direct cell-cell interactions via gap junctions and microtubules or cell fusion. MSCs and GBM paracrine interactions are commonly observed and involve cytokine signaling, regulating MSC tropism toward GBM, their intra-tumoral distribution, and immune system responses. MSC-promoted effects depending on their cytokine and receptor expression patterns are considered critical for GBM progression. MSC origin, tumor heterogeneity and plasticity may also determine the outcome of such interactions. Kinins and kinin-B1 and -B2 receptors play important roles in information flow between MSCs and GBM cells. Kinin-B1 receptor activity favors tumor migration and fusion of MSCs and GBM cells. Flow and image (tissue) cytometry are powerful tools to investigate GBM cell and MSC crosstalk and are applied to analyze and characterize several other cancer types. (AU)

FAPESP's process: 18/07366-4 - Purine and kinin receptors as targets of study and therapeutic interventions in neurological diseases
Grantee:Alexander Henning Ulrich
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 20/10725-6 - Evaluation of purinergic receptors in the comorbidity of bipolar disorder and Alzheimer's Disease
Grantee:Natalia Turrini
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
Grantee:Alexander Henning Ulrich
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/24553-5 - The role of P2Y1 receptor in Parkinsons Disease
Grantee:Roberta Andrejew Caetano
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/26852-0 - Study of purinergic receptors antagonism in the inflammatory process and microglial cells activation using in vitro and in vivo models of Parkinsons Disease
Grantee:Ágatha Oliveira Giacomelli
Support Opportunities: Scholarships in Brazil - Post-Doctorate